… Oncogenic Signaling in Pheochromocytoma and Paraganglioma Recent studies extended
our knowledge on the genetic landscape of pheochromocytoma (PHEO) and paraganglioma (…

… This study establishes Sino-European differences in the genetic landscape and presentation
of PPGLs, including ethnic differences in genotype-phenotype relationships indicating a …

… Integrated genomic analyses have shown that the mutation status of PCC/PGL susceptibility
… genomic and epigenomic alterations. In this review, we discuss the genomic landscape …

The mechanisms triggering metastasis in pheochromocytoma/paraganglioma are unknown,
hindering therapeutic options for patients with metastatic tumors (mPPGL). Herein we show …

… 1 in a paraganglioma. All 4 … of pheochromocytomas, paragangliomas, or other features of
well-known susceptibility syndromes, the authors note that in 1 case a thoracic paraganglioma …

… pheochromocytomas and paragangliomas have substantially advanced our understanding
of cancer biology. This Review addresses the genetic … , including ongoing genomic studies to …

… Similar to other cancer types, the results of this study show that the genetic mutational
landscape of CA-Pheo and CA-Para is broad, and a search for one “magic drug” is unlikely to be …

… Purpose: Pheochromocytoma and paraganglioma (PPGL) … and show that the genetic
landscapes and clonal architectures … Furthermore, we define PPGLs as characterized by genetic …

We report a comprehensive molecular characterization of pheochromocytomas and
paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that PCCs/…

… Altogether, the complete genomic landscape of PCC/PGL is mainly driven by distinct germline
… reveals different molecular entities, characterized by a set of unique genomic alterations. …