… ubiquitously utilized the myo-inositol backbone to generate a diverse array of signalling
molecules. This is achieved by arranging phosphate groups around the six-carbon inositol ring. …

… New and improved methods are necessary to synthesize the pyrophosphate linkage
regiospecifically in the presence of other phosphate groups and to address initial approaches to the …

… inositol phosphate synthesis. A brief introduction to cell signalling is provided and the importance
of the inositol phosphates … Migration of phosphate groups via cyclic intermediates [eg (…

… with the myo-inositol 2-phosphate first prepared by Iselin. A wye-inositol monophosphatehas
… It is optically active and is shown to be myo-inositol 1-phosphate. This suggests that the …

… groups dianionic (Structure 2) and thereby results in significant electrostatic repulsion
between the equatorial phosphate groups. Above pH 9.5 (lO.O-13.01, as the concentration of …

… Their mechanisms of action are far from being elucidated but appear to be closely related
to the number and position of the phosphate groups on the inositol ring. In addition, the …

… inositol phosphates which differ in the number and distribution of phosphate groups around
the inositol … This apparent complexity can be simplified by assigning groups of myo-inositol …

… The electron density map phased on the phosphorus atom revealed oxygen atoms in the
phosphate group and part of the cyclohexane ring. All remaining light atoms except for …

… The number of substituted phosphate groups on the inositol … The positions of the phosphate
groups are denoted by the … stereoisomers other than myoinositol phosphates that rarely exist …

… InsP4 derived from D- and/or L-Ins(l,2,4,5,6)PJ could not possess phosphate groups at both
the D- and L-3 positions]. The alternative explanation for the presence of [3H]Ins amongst …