… cyt c actuates both of these oxidative roles through a uniform mechanism: its … oxidizing the
activating phospholipids. We also show that this new concept is compatible with a leading role …

… oxidation of PS may be mediated via the cytochrome c. To investigate the relationship between
a release of cytochrome c … of exogenous cytochrome c to induce selective oxidation of PS …

… phosphatidylserine externalization. We speculate that selective phosphatidylserine oxidation
could affect phosphatidylserine … Thus, cytochrome c-mediated phosphatidylserine oxidation …

… preferential PS oxidation are not well understood. We hypothesized that cytochrome c (cyt c)
… To further elucidate the role of cyt c in PS oxidation, we integrated it into cyt c null (Cyt c −/−) …

… Since oxidative stress during apoptosis is largely due to disrupted electron transport in … of
cytochrome c (cyt c) from mitochondria into cytosol, we hypothesized that this specific oxidative …

… might be due to the inability of the cells to oxidize critical sulfhydryls. Here we report that
ROS likely play a critical role in sulfhydryl oxidation because ROS-dependent intrinsic apoptosis…

… in which cytochrome c released from mitochondria by oxidative stress binds to phosphatidylserine
located at the cytoplasmic surface of the plasma membrane and induces its oxidation. …

… oxidation of phosphatidylserine (PS) … PS oxidation stimulates its externalization via its effects
on aminophospholipid translocase (APT) or by enhanced PS scrambling, action of oxidized …

… of phospholipid asymmetry and attendant externalization of phosphatidylserine (PS) 4 on the
outer … (ROS), resulting in part from cytochrome c departure from mitochondria and attendant …

… Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with
cardiolipin and phosphatidylserine. Free Radic Biol Med 2004; 37: 1963–1985 [PubMed] [Google …