Photodynamic mechanisms induced by a combination of hypericin and a chlorin based‐photosensitizer in head and neck squamous cell carcinoma cells
EB Gyenge, D Lüscher, P Forny… - Photochemistry and …, 2013 - Wiley Online Library
… Hypericin, a herbal photosensitizer which is the main photoactive constituent from St. Johns
wort was purchased from Invitrogen (Basel, Switzerland). A 1 mg was dissolved in 1 mL 100…
wort was purchased from Invitrogen (Basel, Switzerland). A 1 mg was dissolved in 1 mL 100…
The interaction of hypericin with SARS-CoV-2 reveals a multimodal antiviral activity
P Delcanale, E Uriati, M Mariangeli… - … Applied Materials & …, 2022 - ACS Publications
… of hypericin … hypericin substantially reduce virus infectivity on Vero E6 cells, but a partial
effect is also observed in dark conditions, suggesting multiple mechanisms of action for this drug…
effect is also observed in dark conditions, suggesting multiple mechanisms of action for this drug…
Ratio-dependent effects of photoactivated hypericin and manumycin A on their genotoxic and mutagenic potential
T Zajičková, S Kyzek, I Ďurovcová… - Chemico-Biological …, 2023 - Elsevier
… Our findings indicate that drugs in combinations did not show any mutagenic or cytotoxic
activity. Another important finding refers to the action of given substances (photoactivated …
activity. Another important finding refers to the action of given substances (photoactivated …
Mode of action of hypericin as an antiretroviral agent and other relevant findings
D Meruelo, S Degar, N Amari, Y Mazur, D Lavie… - Natural products as …, 1992 - Springer
… Hypericin usually co-purifies with a congener, pseudohypericin, with the two forming up to
0.… from hypericin by a single hydroxyl group substitution in one methyl group. Hypericin is also …
0.… from hypericin by a single hydroxyl group substitution in one methyl group. Hypericin is also …
Serum albumins are efficient delivery systems for the photosensitizer hypericin in photosensitization-based treatments against Staphylococcus aureus
D Pezzuoli, M Cozzolino, C Montali, L Brancaleon… - Food Control, 2018 - Elsevier
… Proteins are highly biocompatible and warrant good bioavailability of the photoactive
drug. We recently proposed the use of proteins such as apomyoglobin (apoMb) and β-lactoglobulin …
drug. We recently proposed the use of proteins such as apomyoglobin (apoMb) and β-lactoglobulin …
Melanoma-targeted photodynamic therapy based on hypericin-loaded multifunctional P123-spermine/folate micelles
ACV de Oliveira, FAP de Morais… - Photodiagnosis and …, 2022 - Elsevier
Multifunctional P123 micelle linked covalently with spermine (SM) and folic acid (FA) was
developed as a drug delivery system of hypericin (HYP). The chemical structures of the …
developed as a drug delivery system of hypericin (HYP). The chemical structures of the …
Photophysical characterization of Hypericin-loaded in micellar, liposomal and copolymer-lipid nanostructures based F127 and DPPC liposomes
FAP de Morais, RS Gonçalves, KS Campanholi… - … Acta Part A: Molecular …, 2021 - Elsevier
… Hypericin (Hy) compound presents a high photoactivity in photodynamic therapy (PDT),
photodiagnosis and theranostics applications. The maintenance of this compound in monomeric …
photodiagnosis and theranostics applications. The maintenance of this compound in monomeric …
[PDF][PDF] The influence of media polarity and red light on Photofrin II and hypericin
J Kulbacka, D Boehm, A Chwilkowska, J Saczko… - Adv Clin Exp …, 2004 - dbc.wroc.pl
… This triplet state is the photoactive state, which may generate cytotoxic species by … (Photofrin
II and hypericin) in solvents of different polarity and for different con− centration of the dye. …
II and hypericin) in solvents of different polarity and for different con− centration of the dye. …
Hypericin, a medicinal compound from St. John's Wort, inhibits genotoxicity induced by mutagenic agents in V79 cells
LM de Souza, FD de Sousa, RCR Cruz… - Drug and Chemical …, 2022 - Taylor & Francis
… photogenotoxic and phototoxic effects of hypericin photoactive in V79 cells. … hypericin, our
findings allow us to generate discussions about the cytotoxic action mechanism of hypericin …
findings allow us to generate discussions about the cytotoxic action mechanism of hypericin …
Photodynamic effect of hypericin on the conformation and catalytic activity of hemoglobin
J Zhao, W Meng, P Miao, Z Yu, G Li - International Journal of Molecular …, 2008 - mdpi.com
… of hypericin on the conformation and catalytic activity of the protein has also been proven to
be strongly dependent on the irradiation time, the hypericin … light irradiation on hypericin, the …
be strongly dependent on the irradiation time, the hypericin … light irradiation on hypericin, the …