Protoporphyrin IX (PpIX) loaded PLGA nanoparticles for topical Photodynamic Therapy of melanoma cells

DB da Silva, CL da Silva, NN Davanzo… - … and Photodynamic …, 2021 - Elsevier
… ; however, its use in PDT is limited due to its aggregation and low solubility in physiological
media, which can greatly reduce its photodynamic activity. PDT may also be a potential …

PEG-PLGA nanospheres loaded with nanoscintillators and photosensitizers for radiation-activated photodynamic therapy

D Dinakaran, J Sengupta, D Pink, A Raturi, H Chen… - Acta Biomaterialia, 2020 - Elsevier
… However, PDT is … nanoparticles, which have shown potential benefits for PDT of deep-seated
tumors. Herein, the design and use of a new nanoscintillator-based radiation-activated PDT

Zinc (II) phthalocyanine loaded PLGA nanoparticles for photodynamic therapy use

E Ricci-Júnior, JM Marchetti - International journal of pharmaceutics, 2006 - Elsevier
… on biodegradable polymers such as PLGA. This polymer has … PLGA has been approved
by FDA and has been used in … photosensitizer for PDT loaded with PLGA nanoparticles was …

In vitro and in vivo characterization of temoporfin-loaded PEGylated PLGA nanoparticles for use in photodynamic therapy

M Rojnik, P Kocbek, F Moret, C Compagnin… - …, 2012 - Taylor & Francis
… The aim of this study was to prepare a PLGA NP delivery system loaded with the PS temoporfin
to be used in PDT. PLGA NPs were optimized with respect to their average particle size, …

… the understanding of the photodynamic activity of m-THPP encapsulated in PLGA nanoparticles: correlation between nanoparticle properties and in vivo activity

A Vargas, N Lange, T Arvinte, R Cerny… - Journal of drug …, 2009 - Taylor & Francis
… Similarly, the 117 nm batch exhibited the highest in vivo photodynamic activity, as … illumination
is an important step for in vivo photodynamic activity especially for large NP. The NP size …

Zinc phthalocyanine-loaded PLGA biodegradable nanoparticles for photodynamic therapy in tumor-bearing mice

M Fadel, K Kassab, D Abdel Fadeel - Lasers in medical science, 2010 - Springer
… in PLGA nanoparticles is a successful delivery system for improving photodynamic
activity … as vehicles for photosensitizer and evaluate the photodynamic activity in vivo. The …

Preparation, characterization, photocytotoxicity assay of PLGA nanoparticles containing zinc (II) phthalocyanine for photodynamic therapy use

E Ricci-Júnior, JM Marchetti - Journal of microencapsulation, 2006 - Taylor & Francis
… on biodegradable polymers such as PLGA. These polymers have … PLGA has been approved
by FDA and has been used in … photosensitizer for PDT-loaded PLGA nanoparticles was …

Improved photodynamic activity of porphyrin loaded into nanoparticles: an in vivo evaluation using chick embryos

A Vargas, B Pegaz, E Debefve… - International journal of …, 2004 - Elsevier
… are potentially interesting molecules for the photodynamic therapy (PDT) of solid cancers
or … ) (PLGA) nanoparticles proved to enhance its photodynamic activity against mammary …

Nanoparticles in photodynamic therapy: an emerging paradigm

DK Chatterjee, LS Fong, Y Zhang - Advanced drug delivery reviews, 2008 - Elsevier
… in vivo photodynamic activities of verteporfin-loaded PLGA nanoparticles were investigated.
… to be intravenously injected and improve the photodynamic activity of the photosensitizer [22]…

Encapsulation of p‐THPP into Nanoparticles: Cellular Uptake, Subcellular Localization and Effect of Serum on Photodynamic Activity

YN Konan, J Chevallier, R Gurny… - Photochemistry and …, 2003 - Wiley Online Library
… profiles and drug pharmaceutical activities by choosing the appropriate polymer. Indeed,
among the formulations tested, the efficiency of 50:50 PLGA nanoparticles was found to be …