… , our results show that loss of PKM2 reduced the thickness of the photoreceptor end tips.
Our data suggest that PKM2 is important for the maintenance of photoreceptor structure. …

… Similar to cancer cells, retinal photoreceptors predominantly … in photoreceptor cells. This
review focuses on the metabolic and non-metabolic roles of pyruvate kinases in photoreceptor …

… The tumor form of pyruvate kinase M2 has been suggested to … photoreceptors express
the tumor form of pyruvate kinase M2… important for rod photoreceptor structure, function, and …

… Our biochemical characterization of pyruvate kinase in isolated rod and cone photoreceptors
clearly shows the expression of both PKM1 and PKM2 isoforms. It is interesting to note that …

… Photoreceptor cell death is the ultimate cause of vision loss in many retinal disorders, and
… photoreceptor survival. Similar to cancer cells, photoreceptors maintain pyruvate kinase …

… is critical to photoreceptor function and survival [3,5,11,12]. Pyruvate kinase muscle isoform
2 (… the penultimate step of glycolysis, producing pyruvate and adenosine triphosphate (ATP) …

… Results: Pyruvate kinase M2 was present in some glial cells and rod and cone photoreceptors
in the retina … Pyruvate kinase M1 was confined to neurons in the retina and brain. Lactate …

… The M2 isoform of pyruvate kinase (PKM2) is … find that photoreceptors (PRs) in retinas, like
cancer cells in tumors, express PKM2. We also found very little expression of pyruvate kinase (…

… photoreceptor cell death. Our laboratory has shown that reprogramming photoreceptor …
However, the low aqueous solubility and structural features of the lead compound, ML-265, …

… The molecular switch controlling glycolytic flow is thought to be the M2 isoenzyme of pyruvate
kinase (PKM2). PKM1 and PKM2 are both present in the mouse retina. However, the outer …