Phylogenomics with paralogs
M Hellmuth, N Wieseke, M Lechner… - Proceedings of the …, 2015 - National Acad Sciences
… the distribution of paralogs in large gene families contains in itself sufficient phylogenetic
signal to infer fully resolved species phylogenies. This source of phylogenetic information is …
signal to infer fully resolved species phylogenies. This source of phylogenetic information is …
New approaches for inferring phylogenies in the presence of paralogs
… used in phylogenomic inference: one that still includes only orthologs and one that includes
both orthologs and paralogs. We also describe the newly developed phylogenetic methods …
both orthologs and paralogs. We also describe the newly developed phylogenetic methods …
The impact of paralogy on phylogenomic studies–a case study on annelid relationships
TH Struck - PloS one, 2013 - journals.plos.org
… in such analyses, but it is rarely assessed whether paralogous sequences have … the
phylogenetic reconstruction using a super-matrix approach. Herein, I tested the impact of paralogous …
phylogenetic reconstruction using a super-matrix approach. Herein, I tested the impact of paralogous …
Phylogenomics: gene duplication, unrecognized paralogy and outgroup choice
SW Roy - PLoS One, 2009 - journals.plos.org
… in the presence of NST signal arising from subsets of unrecognized paralogs genes within
… First, I consider phylogenetic analysis of concatenated alignments across putative orthologs. …
… First, I consider phylogenetic analysis of concatenated alignments across putative orthologs. …
A new pipeline for removing paralogs in target enrichment data
… As such, we recommend that phylogenomic analyses account for paralogs, such as through
our PPD tool, particularly when the study group of interest belongs to lineages where gene …
our PPD tool, particularly when the study group of interest belongs to lineages where gene …
Inadvertent paralog inclusion drives artifactual topologies and timetree estimates in phylogenomics
K Siu-Ting, M Torres-Sánchez… - Molecular Biology …, 2019 - academic.oup.com
… Taking a phylogenomic approach and focusing on the Lissamphibia group, we test the
hypothesis that inadvertent paralog inclusion is driving the observed highly supported yet …
hypothesis that inadvertent paralog inclusion is driving the observed highly supported yet …
More-curated data outperforms more data: Treatment of cryptic and known paralogs improves phylogenomic analysis and resolves a northern Andean origin of …
L Frost, L Lagomarsino - bioRxiv, 2021 - biorxiv.org
… phylogenomic complexity in Freziera, including the presence … that artifactual orthologs (ie,
the presence of only one copy of a … a negative impact on phylogenetic inference and support. …
the presence of only one copy of a … a negative impact on phylogenetic inference and support. …
Functional annotations of paralogs: a blessing and a curse
R Zallot, KJ Harrison, B Kolaczkowski… - Life, 2016 - mdpi.com
… Unfortunately, rigorous phylogenetic analysis does not scale well computationally, making
it difficult to apply the most accurate tree reconstruction algorithms to large data sets [71,101]. …
it difficult to apply the most accurate tree reconstruction algorithms to large data sets [71,101]. …
Species tree inference methods intended to deal with incomplete lineage sorting are robust to the presence of paralogs
… : from explicitly denoting them as paralogs, to randomly … analyses using single-copy orthologs.
Our results have significant implications for the use of ILS-aware phylogenomic analyses, …
Our results have significant implications for the use of ILS-aware phylogenomic analyses, …
Functional diversification of sonic hedgehog paralog enhancers identified by phylogenomic reconstruction
… Here, we propose that the presence or absence of the C4 site functions as a binary switch
to modulate ar-C enhancer activity specific to one of two midline tissues after gene duplication. …
to modulate ar-C enhancer activity specific to one of two midline tissues after gene duplication. …