Physicochemical aspects of the tumour microenvironment as drivers of vasculogenic mimicry

E Andreucci, S Peppicelli, J Ruzzolini… - Cancer and Metastasis …, 2022 - Springer
… Among the mechanisms identified to contribute to tumour vascularisation, vasculogenic
mimicry (VM) is gaining increasing interest in the scientific community representing an intriguing …

Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin

D Delgado-Bellido, S Serrano-Saenz… - Molecular cancer, 2017 - Springer
… Finally, Wnt proteins may promote vasculogenic mimicry through the activation of PKC
and PI3K signaling, though it could play a role in tumor suppression in certain cases …

Pro-angiogenic activity and vasculogenic mimicry in the tumor microenvironment by leptin in cancer

AK Herrera-Vargas, E Garcia-Rodriguez… - Cytokine & growth factor …, 2021 - Elsevier
… of angiogenesis and vasculogenic mimicry in different types of … various angiogenic factors
and vasculogenic mimicry. In vivo models, … between leptin and vasculogenic mimicry was more …

Vasculogenic mimicry: a pivotal mechanism contributing to drug resistance in antiangiogenic therapy

SM Dang, D Yang, ZY Wang, XM Ding… - Oncology and …, 2024 - journals.lww.com
… In recent years, vasculogenic mimicry (VM) has attracted increasing attention from the …
Physicochemical aspects of the tumour microenvironment as drivers of vasculogenic mimicry

Glioblastoma vasculogenic mimicry: signaling pathways progression and potential anti-angiogenesis targets

J Mao, J Liu, G Guo, X Mao, C Li - Biomarker Research, 2015 - Springer
… Schematic model of signaling pathways implicated in glioma vasculogenic mimicry (VM).
The whole VM process proceeds under the condition of hypoxia. Only signaling molecules …

Multi-targeting peptide-functionalized nanoparticles recognized vasculogenic mimicry, tumor neovasculature, and glioma cells for enhanced anti-glioma therapy

X Feng, J Yao, X Gao, Y Jing, T Kang… - … applied materials & …, 2015 - ACS Publications
Physicochemical properties of nanoparticles are the critical factors affecting the pharmacokinetics
(PK), biodistribution, and intratumoral penetration of nanoparticles. (33) Therefore, …

Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) enzymes as an emerging therapeutic strategy to target angiogenesis and vasculogenic mimicry in …

JA Hulin, EA Gubareva, N Jarzebska… - Frontiers in …, 2020 - frontiersin.org
… Despite its short half-life, NO has a unique ability, as a result of its physicochemical properties,
to diffuse over long distances (several 100 μ) within milliseconds. In addition, in contrast …

Functional roles of microRNAs in vasculogenic mimicry and resistance to therapy in human cancers: an update

AP García-Hernández… - Expert Review of …, 2024 - Taylor & Francis
Vasculogenic mimicry (VM) alludes to the ability of cancer cells to organize on three-dimensional
channels-like structures to obtain nutrients and oxygen. This mechanism confers an …

Multifunctional tandem peptide modified paclitaxel-loaded liposomes for the treatment of vasculogenic mimicry and cancer stem cells in malignant glioma

Y Liu, L Mei, Q Yu, C Xu, Y Qiu, Y Yang… - … applied materials & …, 2015 - ACS Publications
… The chemical and physical properties including size, surface charge, and surface
chemistry are important factors that determine the pharmacokinetics and biodistribution of …

VE-Cadherin in cancer-associated angiogenesis: A deceptive strategy of blood vessel formation

D Delgado-Bellido, FJ Oliver… - International Journal of …, 2023 - mdpi.com
… The term “vascular mimicry” has also been used simultaneously with VM. Nevertheless,
vascular mimicry has immense implications as it includes other cell-associated phenotypes, …