… formalin test to study the neurochemical basis of nociceptive mechanisms at the spinal level
and searched for a physiological … of formalin with those produced by two formalin injections …

… The formalin test was introduced as a model of tonic pain in 1977, and has since been used
extensively in rats and mice. In rats, formalin … Electrophysiological evidence for a role of …

… Several lines of evidence indicate that the early phase of the formalin response is caused
by a direct effect of the noxious agent on nociceptors followed by an activation of C-fibers, …

… physiological measures provided convergent evidence of nociceptive and antinociceptive
processes in the mouse formalin test… to occur in the mouse formalin test, we did not record this …

… guinea pigs show biphasic pain in the formalin test, whereas larger mammals such as cats,
… our recent work on the formalin test. However, it provided convergent evidence that it is the …

… More than 3 decades after the formalin test was devised, this article describes a temporary
neuronal hyperpolarization induced by formaldehyde and demonstrates that this is necessary …

… , formalin elicits robust, spontaneous behavioral responses (Wheeler-Aceto et al. 1990).
We propose that, of the agents tested, formalin … defining any physiological and anatomical …

… evidence for an excitatory role of adrenergic mechanisms in pain. Only one study presents
evidence … Wall, PD and Gutnik, M., Ongoing activity in peripheral nerves: the physiology and …

… Further to these ethical considerations, and of particular relevance to the formalin test, other
evidence suggests that restraining also induces stress, behavioural and other physiological …

… This is particularly important for pharmacological and physiological studies, where it is
necessary to … Other evidence supporting the log-linear nature of the formalin concentration–effect …