Antinociceptive effects of haloperidol and its metabolites in the formalin test in mice

CM Cendán, JM Pujalte, E Portillo-Salido… - …, 2005 - Springer
… in the second phase of the formalin test, but was less potent … in either phase of the formalin
test. The order of potency of the … formalin test produced any antinociception in the tail flick test

Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats

AB Malmberg, TL Yaksh - Pain, 1993 - Elsevier
… min; ED 50 , 135 and 246 nmol) of the formalin test with minimal effect on the first phase (0–9
min… formalin response by l-NAME was similar whether administered before or after formalin

The effects of prior chronic stress on cardiovascular responses to acute restraint and formalin injection

S Bhatnagar, MF Dallman, RE Roderick, AI Basbaum… - Brain research, 1998 - Elsevier
… seen in our study since there is no evidence for increased resting HPA activity in this … and
formalin, we believe these data are critical to our understanding of the physiological effects of …

Effect of picrotoxin on antinociception in the formalin test

MR Heidari, F Khalili, M Ghazi‐Khansari… - Pharmacology & …, 1996 - Wiley Online Library
… Our results show that the formalin test is a valuable method to investigate antinociception
induced by picrotoxin. The pain response induced by formalin was biphasic, the first phase …

Adolescent morphine exposure increases nociceptive behaviors in rat model of formalin test

E Ghasemi, N Pachenari… - Developmental …, 2019 - Wiley Online Library
… Up until now, there has been no evidence regarding the long‐term effect of … , formalin test
was performed. To evaluate morphine analgesia, in a separate group of animals, formalin test

Intrathecal co-administration of substance P and NMDA augments nociceptive responses in the formalin test

N Mjellem-Joly, A Lund, OG Berge, K Hole - Pain, 1992 - Elsevier
… Electrophysiological studies have shown that receptors of … in the 2nd phase of the formalin
test. This was unexpected in … Apart from the fact that in the formalin test a different and more …

Evaluating the antinociceptive efficacy of cannabidiol alone or in combination with morphine using the formalin test in male and female mice

DE Sepulveda, DP Morris… - Cannabis and …, 2022 - liebertpub.com
… There is mixed evidence that activation of the endocannabinoid system is effective in …
Therefore, we expect that the physiological effects of CBD were active throughout the entirety of our …

Analgesia produced by centrally administered DAGO, DPDPE and U50488H in the formalin test

DJ Calcagnetti, FJ Helmstetter, MS Fanselow - European journal of …, 1988 - Elsevier
… Several independent lines of evidence have established the existence of at least three …
Based upon their anatomical and physiological properties they can be divided into two groups: (1…

Restraint reduces formalin-test pain but the effect is not influenced by lesions of the hypothalamic paraventricular nucleus

PN Fuchs, R Melzack - Experimental neurology, 1996 - Elsevier
… Of particular interest is the evidence indicating the importance of the paraventricular
nucleus of the … In addition, it is well established that there are anatomical and neurophysiological

Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like1 receptor agonist, in the rat formalin test

T Yamamoto, N Nozaki-Taguchi, S Kimura - Neuroscience, 1997 - Elsevier
… Although there is no evidence that nociceptin prevents the release of substance P in the spinal
… of nociceptin induces an analgesic effect on the formalin test, but not on the hot plate test. …