… We describe a six-compartment physiological model of the kinetics and dynamics of
induction of anaesthesia with propofol in sheep. It includes a faithful description of initial bolus …

… of different models will be identified to describe physiological and anthropometric variables
… However, in order to estimate valid and unbiased body mass exponents when investigating …

… INTRODUCTION ter estimation from noisy data in physiological modeling. WLS can be …
error-in-variables problem [3]. estimates than WLS (when the underlying model is correct). …

… An initial estimate of the parameters is usually … variable that represents the amount by which
the measured value of the dependent variable, y, deviates from the value given by the model …

… Typically, the recorded data are transformed from measurement data into estimates of the
variables used in the model. Collecting appropriate data is usually the most difficult aspect of …

… the interacting dynamic variables, and subsequently use the model structure to predict what
… extraction, model building, parameter estimation, and prediction using the model lies at the …

… Models of physiological systems are represented for … variable and with parameter vector .
We consider single-output … how these model output variations would affect parameter estimates.…

… the separations found in a graphical model. For estimation of the partial spectral coherences
from multivariate time series representing physiological variables we use the program "…

… model of the system exists (with some known structure but unknown parameters) and when
a sufficient number of the state variables of … the computer models and parameter estimation …

… based on average values of hemodynamic variables measured a few minutes after the …
estimates. Since treatment of ill-conditioning is not commonly found in the physiological modeling …