… partially mediated by activation of PI3K/Akt and MAPK/ERK pathways. … Akt and ERK1/2
activation. One of possible explanations was that exosome-induced Akt and ERK1/2 activation …

… In this review we shall discuss why the PI3K/AKT/mTOR and Raf/MEK/ERK signaling … -IRS1-PI3K)
leads to activation of PI3K but also ERK signaling. PI3K and ERK signaling converge …

… with the activation of ERK, Akt, and eNOS … , PI3K, and eNOS. These results suggest that
icariin possesses potent angiogenic activity through the activation of the MEK/ERK- and PI3K/Akt/…

… with activation of the MAPK pathway. In terms of the PI3K/Akt pathway, we did not see any
… phosphorylation of TSC2 by Akt nor the anticipated changes secondary to Akt in mTOR or …

… The PI3K pathway has been shown to be activated due to the loss or down regulation of
PTEN which is an important tumor suppressor protein encoding phosphatidylinositol-3,4,5- …

… In this study, the effects of activated Raf (Raf-1, A-Raf and B-Raf) and PI3K/Akt proteins
on abrogation of cytokine dependence in FL5.12 hematopoietic cells were examined. …

… effect of leptin on the activation of the JAK/STAT-AKT-ERK pathway. Our experiments clearly
… /STAT pathway and induced the phosphorylation of ERK and AKT, thus activating these key …

… /MEK/ERK and PI3K/Akt signaling pathways are activated by a … cytokine signaling activates
JAK/STAT, Raf/MEK/ERK and PI3K/Akt … The JAK/STAT, Raf/MEK/ERK and PI3K/Akt signaling …

… ), LY294002 (PI3K inhibitor), or U0126 (MEK1/2 inhibitor), we show that Erk- mediated
downstream activation of PI3K/Akt pathway results in resistance to Akt inhibition. These provide …

The PI3K/AKT/mTOR pathway is frequently activated in advanced prostate cancer, due to
loss of the tumour suppressor PTEN, and is an important axis for drug development. We have …