Crosstalk between MAPK/ERK and PI3K/AKT signal pathways during brain ischemia/reperfusion

J Zhou, T Du, B Li, Y Rong, A Verkhratsky… - ASN neuro, 2015 - journals.sagepub.com
… investigated the activation of EGFR, PI3K/AKT, and Raf/MAPK/ERK 1/2 during ischemia …
PI3K/AKT pathway was significantly increased, as judged from the strong phosphorylation of AKT

The role of PI3K/Akt and ERK in neurodegenerative disorders

SN Rai, H Dilnashin, H Birla, SS Singh, W Zahra… - Neurotoxicity …, 2019 - Springer
… Some of these components are cytosolic targets of ERK, thus implicating MAPK pathway
in formation/maintenance of such pathological hallmark, and therefore in the noxious events …

Phosphorylation of PI3K/Akt and MAPK/ERK in an early entry step of enterovirus 71

WR Wong, YY Chen, SM Yang, YL Chen, JT Horng - Life sciences, 2005 - Elsevier
… We demonstrate here that GSK3 is regulated both by MAPK/ERK and PI3K/Akt in EV71-infected
cells. Thus, it is proposed that ERK1/2 and Akt signaling can cooperate to reduce the …

Gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activation

JL Qu, XJ Qu, MF Zhao, YE Teng, Y Zhang… - Digestive and liver …, 2009 - Elsevier
… Since PI3K/Akt and MAPK/ERK pathways play an important … whether the activation of PI3K/Akt
and MAPK/ERK signalling was … to suppress PI3K/Akt and MAPK/ERK signalling pathways, …

The roles of PI3K/AKT/mTOR and MAPK/ERK signaling pathways in human pheochromocytomas

J Du, A Tong, F Wang, Y Cui, C Li… - International Journal …, 2016 - Wiley Online Library
… these two vital cellular pathways, PI3K/AKT/mTOR and MAPK/ERK, in PPGLs. In this
study, we examined the effect of PI3K/AKT/mTOR and MAPK/ERK pathways on the growth of …

[HTML][HTML] Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer

SK Roy, RK Srivastava, S Shankar - Journal of molecular signaling, 2010 - Springer
… that inhibition of PI3K/AKT and MEK/ERK pathways act synergistically … PI3K/AKT and ERK
pathways activates FOXO transcription factors. SFN inhibited phosphorylation of AKT and ERK

[PDF][PDF] A minireview: the role of MAPK/ERK and PI3K/Akt pathways in thyroid follicular cell-derived neoplasm

E Brzezianska… - Front Biosci (Landmark …, 2011 - article.imrpress.com
… Genetic and epigenetic alternations, concerning MAPK/ERK and PI3K/Akt signaling
pathways, contribute to their activation and interaction in consequence of malignant follicular cell …

Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways

X Liang, Y Ding, F Lin, Y Zhang, X Zhou… - The FASEB …, 2019 - Wiley Online Library
… Inhibition of PI3K/AKT or MAPK/ERK pathway greatly increased cell senescence in … and the
effect of PI3K/AKT pathway was more prominent than MAPK/ERK pathway (Supplemental Fig…

[HTML][HTML] … -induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway

T Wang, S Seah, X Loh, CW Chan, M Hartman… - Oncotarget, 2016 - ncbi.nlm.nih.gov
… in the PI3K/Akt/mTOR pathway relative to the MAPK/ERK pathway. We acknowledge that
our observation of differential time-based response of PI3K/Akt/mTOR and MAPK/ERK is on a …

γ-Enolase C-terminal peptide promotes cell survival and neurite outgrowth by activation of the PI3K/Akt and MAPK/ERK signalling pathways

A Hafner, N Obermajer, J Kos - Biochemical Journal, 2012 - portlandpress.com
… γ-Enolase acts via the PI3K/Akt and MAPK/ERK signalling pathways We assessed the
degree of activation of the PI3K/Akt and MAPK/ERK pathways that have been shown to be …