PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment

A Guerrero-Zotano, IA Mayer, CL Arteaga - Cancer and Metastasis …, 2016 - Springer
… are freqcuently found in breast cancers and associated with cellular transformation,
tumorigenesis, cancer progression, and drug resistance. Several drugs targeting PI3K/ATK/mTOR …

Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

C Xue, G Li, J Lu, L Li - Signal transduction and targeted therapy, 2021 - nature.com
… Clinical trials targeting PI3K have also attracted increasing attention. Emerging … with the
PI3K/AKT pathway to regulate cancer progression. Importantly, circRNAs related to the PI3K/AKT

The PI3K/AKT pathway as a target for cancer treatment

IA Mayer, CL Arteaga - Annual review of medicine, 2016 - annualreviews.org
… Several studies using GEMs subsequently showed that tissue-specific expression of mutant
PIK3CA can induce tumor formation and accelerate cancer progression (13–15). PIK3CD …

PI3K/Akt signalling pathway and cancer

JÁF Vara, E Casado, J de Castro, P Cejas… - Cancer treatment …, 2004 - Elsevier
… of cell survival, cell cycle progression and cellular growth. In recent years, it has been
shown that PI3K/Akt signalling pathway components are frequently altered in human cancers. …

PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance

MP Edlind, AC Hsieh - Asian journal of andrology, 2014 - journals.lww.com
… direct connection between the PI3K-AKT-mTOR and androgen … number of novel inhibitors
of the PI3K pathway, which offer the … of the PI3K-AKT-mTOR pathway in PCa progression and …

The relation between PI3K/AKT signalling pathway and cancer

S Noorolyai, N Shajari, E Baghbani, S Sadreddini… - Gene, 2019 - Elsevier
… a challenge for cancer therapy. The high recurrence of phosphoinositide 3-kinase (PI3K)
pathway adjustments in cancer has led to a surge in the progression of PI3K inhibitors. Recent …

SLC1A3 promotes gastric cancer progression via the PI3K/AKT signalling pathway

L Xu, J Chen, L Jia, X Chen… - Journal of cellular …, 2020 - Wiley Online Library
… The PI3K/AKT signalling pathway has … of PI3K/AKT signalling in gastric cancer progression
is well established, little is known about the role of SLC1A3 in the regulation of the PI3K/AKT

The importance of the PI3K/AKT/MTOR pathway in the progression of ovarian cancer

ZC Dobbin, CN Landen - International journal of molecular sciences, 2013 - mdpi.com
… One such pathway is the PI3K/AKT/… PI3K/AKT/mTOR pathway. In this review, the focus will
be on recent research implicating the PI3K/AKT/mTOR pathway in ovarian cancer progression

PI3K/AKT signaling tips the balance of cytoskeletal forces for cancer progression

S Deng, HC Leong, A Datta, V Gopal, AP Kumar… - Cancers, 2022 - mdpi.com
… between cytoskeletal proteins and the PI3K/AKT signaling pathway, and how … aids cancer
progression. Our review also summarizes recent advances in the clinical development of PI3K

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy

F Chang, JT Lee, PM Navolanic, LS Steelman… - Leukemia, 2003 - nature.com
… that the PI3K/Akt pathway is a viable target for novel antineoplastic drugs. This review will
describe PI3K/Akt pathway signaling and its effects on cell cycle progression, prevention of …