… of the contributions made by the PI3K/Akt pathway in thymocyte development has not been
… the PI3K/Akt pathway is essential for thymocyte survival. We provide new evidence that Akt-…

… cells – have highlighted the importance of this pathway to development and cellular
differentiation… Here, we review the recent in vitro and in vivo evidence for the role PI3K/AKT/mTOR …

… cells, 33 and T cells, 34–38 among others. This review will focus on how PI3K/AKT signaling
contributes to the development and stability of natural and induced regulatory T cells, a …

… of regulatory T cells. However, the role of endogenous PI3K-AKT in T-cell development …
Here, we inhibited the endogenous PI3K-AKT pathway in thymocytes after double negative …

… factors that orchestrate B-cell differentiation and specialization. Herein, we … the PI3K-AKT-dependent
signal transduction and their impact on early B-cell development, peripheral B-cell …

… the formation of the germ cell precursors, termed primordial germ cells, and the follicular …
role of the PI3K/PTEN/AKT pathways during primordial germ cell development and the …

… Used alone or in combination with existing therapies, these inhibitors of the PI3K/Akt pathway
will be developed to exploit activation of the PI3K/Akt pathway within cancer cells and/or …

… develop an in vitro cell culture system to serve as a model to study the PI3K/Akt pathway in
the developing … the expression and function of PI3K and Akt in trophoblast stem (TS) cells. TS …

… The phosphatidylinositol-3 kinase (PI3K)–AKT PI3K-AKT pathway is … development of
squamous cell cancers 34. In addition, the expression of either human wild-type AKT or myr-AKT in …

… However, activation of the PI3K/AKT pathway in tumor cells can also increase … PI3K/AKT
pathway is important not only in the development of cancers but also for signaling in normal cells…