A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition

W Xu, Z Yang, N Lu - Cell adhesion & migration, 2015 - Taylor & Francis
… Osthole inhibits insulin-like growth factor-1-induced epithelial to mesenchymal transition via
the inhibition of PI3K/Akt signaling pathway in human brain cancer cells. J Agric Food Chem …

PI3K/AKT pathway and the epithelial-mesenchymal transition

A Bellacosa, L Larue - Cancer genome and tumor microenvironment, 2010 - Springer
… While many of the downstream effectors of the AKT pathway are involved in … AKT signaling
for epithelialmesenchymal transition, in particular on the PI3KAKT–NF-κB–Snail pathway

Role of AKT and mTOR signaling pathways in the induction of epithelial-mesenchymal transition (EMT) process

MK Roshan, A Soltani, A Soleimani, KR Kahkhaie… - Biochimie, 2019 - Elsevier
… The PTEN/PI3K pathway dysregulation is known to be involved in many cancer types [40].
Loss of PTEN function causes hyperactivation of PI3K/AKT signaling resulting in increased …

PI3K/AKT signaling pathway as a critical regulator of epithelial-mesenchymal transition in colorectal tumor cells

A Maharati, M Moghbeli - Cell Communication and Signaling, 2023 - Springer
… the role of PI3K/AKT pathway CRC metastasis through the … PI3K/AKT pathway can induce
the EMT process by down regulation of epithelial markers, while up regulation of mesenchymal

Acquisition of epithelialmesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer …

L Chang, PH Graham, J Hao, J Ni, J Bucci… - Cell death & …, 2013 - nature.com
epithelialmesenchymal transition (EMT), cancer stem cells (CSCs) and the PI3K/Akt/mTOR
signaling pathway … and Chk2) and the PI3K/Akt/mTOR signaling pathway proteins were also …

TACC3 promotes epithelialmesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways

GH Ha, JS Park, EKY Breuer - Cancer letters, 2013 - Elsevier
… a novel mechanism by which TACC3 regulates epithelialmesenchymal transition (EMT).
By … Moreover, phosphatidylinositol 3-kinase (PI3K)/Akt and extracellular signal-regulated …

The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer

P Dong, Y Konno, H Watari, M Hosaka… - Journal of translational …, 2014 - Springer
… Activation of the PI3K/AKT pathway, a common mechanism … roles in contributing to
epithelial-mesenchymal transition (EMT) … cancer via regulating PI3K/AKT pathway. MiRNAs are …

Activation of IL-8 via PI3K/Akt-dependent pathway is involved in leptin-mediated epithelial-mesenchymal transition in human breast cancer cells

L Wang, C Tang, H Cao, K Li, X Pang… - Cancer biology & …, 2015 - Taylor & Francis
… that are regulated by JAK/STAT, PI3K/AKT, and MAPK/ERK … epithelial-mesenchymal
transition of human breast cancer cells and induced IL-8 expression via PI3K/Akt signaling pathway

Epithelialmesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways

L Larue, A Bellacosa - Oncogene, 2005 - nature.com
… Recently, activation of the phosphatidylinositol 3′ kinase (PI3K)/AKT axis is emerging
as a central feature of EMT. In this review, we discuss the role of PI3K/AKT pathways in EMT …

Involvement of PI3K/Akt Pathway in TGF-β2-Mediated Epithelial Mesenchymal Transition in Human Lens Epithelial Cells

K Yao, PP Ye, J Tan, XJ Tang, XC Shen Tu - Ophthalmic research, 2008 - karger.com
… 24 Cho HJ, Baek KE, Saika S, Jeong MJ, Yoo J: Snail is required for transforming growth
factor- ß -induced epithelial mesenchymal transition by activating PI3 kinase/Akt signal pathway