… 3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling pathways
are … of the development of specific PI3K, Akt, and mTOR inhibitors, from already registered …

… PI3K/AKT/mTOR pathway in the design of effective personalized treatment strategies. Here
we report a comprehensive PI3K/AKT/mTOR … to study the AKT signalling mechanism in detail …

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway
is activated in the majority of human cancers. This pathway is known to play a key role in …

… 3-kinase (PI3K)–AKT–mammalian target of rapamycin (mTOR) pathway as a key
potential … Finally, we discuss the issues and limitations involved with targeting the PI3K–AKT–mTOR …

… The PI3K/AKT/mTOR pathway is frequently activated in various human … PI3K/AKT/mTOR
axis, including the catalytic (p110α) and regulatory (p85α), of class IA PI3K, AKT, RHEB, mTOR, …

… It is well established that the PI3K pathway plays a central role in various cellular processes
that … Novel inhibitors of PI3K, Akt, and mTORC1 and 2 are now passing through early phase …

… benefit from inhibition of the PI3K/Akt/mTOR (PAM) pathway. … limited to mTOR inhibitors with
everolimus, an mTOR inhibitor… include the PI3K inhibitors, Akt inhibitors, and the dual mTOR …

… Substantial progress in uncovering PI3K/AKT/mTOR … , exemplify targeted inhibition of
PI3K/AKT/mTOR in the clinic and many … This review focuses on targeted PI3K/AKT/mTOR …

… Moreover, activation of the Akt/mTOR pathway confers … , such as the Akt inhibitors perifosine
and PX-866 and mTOR inhibitors (… regulation of the PI3K/Akt/mTOR pathway poses practical …

… of the PI3K/Akt pathway and sufficient nutrients, mTOR stimulates … PI3K signaling is terminated
by degradation of PIP 3 , which … of AKT and upregulation of mTOR-dependent pathways. …