PI3K/AKT signaling pathway and cancer: an updated review

M Martini, MC De Santis, L Braccini, F Gulluni… - Annals of …, 2014 - Taylor & Francis
… , and PI3K-C2γ), and it remains the most enigmatic among all PI3Ks, despite recent studies
providing novel clues about its role in signal … Overview of PI3K/AKT/mTOR signaling pathway. …

[HTML][HTML] The pathogenic role of PI3K/AKT pathway in cancer onset and drug resistance: an updated review

F Rascio, F Spadaccino, MT Rocchetti, G Castellano… - Cancers, 2021 - mdpi.com
… and also includes clinical trials to test new therapeutic strategies. In this review, we will
highlight the emerging role of the PI3K/Akt pathway in drug resistance by discussing recent

The relation between PI3K/AKT signalling pathway and cancer

S Noorolyai, N Shajari, E Baghbani, S Sadreddini… - Gene, 2019 - Elsevier
Recent developments incorporate a re-assessment of the oncogenic mechanisms behind
PI3K pathway … In this review, we consider about the phosphoinositide 3-kinases family and …

PI3K/Akt signalling pathway and cancer

JÁF Vara, E Casado, J de Castro, P Cejas… - … treatment reviews, 2004 - Elsevier
… understanding of PI3K/Akt signalling pathway may improve the … In the present review, we
discuss PI3K/Akt pathway components … Moreover, we describe the current status of the different …

The PI3K/AKT/mTOR signaling pathway in breast cancer: Review of clinical trials and latest advances

ABS Khorasani, N Hafezi, MJ Sanaei… - Cell Biochemistry …, 2024 - Wiley Online Library
… the analysis of trials evaluating PI3K pathway inhibitors. Therefore, the aim of the current
study is not only to provide an overview of how alterations of the PI3K axis could influence BC …

[HTML][HTML] The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review

K Sun, J Luo, J Guo, X Yao, X Jing, F Guo - Osteoarthritis and cartilage, 2020 - Elsevier
… how this signaling pathway affects development of the disease. We also summarize recent
evidences of therapeutic approaches to treat OA by targeting the PI3K/AKT/mTOR pathway, …

A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition

W Xu, Z Yang, N Lu - Cell adhesion & migration, 2015 - Taylor & Francis
… The PI3K/Akt signaling pathway mediates the process of EMT and … review investigated the
regulatory mechanisms of EMT, which are strongly related to the PI3K/Akt signaling pathway

[HTML][HTML] Targeting PI3K/Akt signal transduction for cancer therapy

Y He, MM Sun, GG Zhang, J Yang, KS Chen… - Signal transduction and …, 2021 - nature.com
… In conclusion, inhibition of the PI3K/Akt signaling pathway, which has been shown to regulate
cancer cell apoptosis, can serve as a new direction for future research on cancer treatment…

[HTML][HTML] Targeting PI3K/AKT/mTOR signaling pathway in breast cancer

H Li, L Prever, E Hirsch, F Gulluni - Cancers, 2021 - mdpi.com
… In this review, we provide a perspective on the role of the PI3K … Here we summarize the
most recent advances in the inhibition of the PI3K/AKT/mTOR signaling pathway in breast cancer. …

[HTML][HTML] A new therapeutic trend: natural medicine for ameliorating ischemic stroke via PI3K/Akt signaling pathway

X Liu, X Xiao, X Han, L Yao, W Lan - Molecules, 2022 - mdpi.com
… In this paper, we reviewed the evidence for natural medicine treatment of IS through the
PI3K/Akt signaling pathway in recent years. We also explained its mechanism to provide new