PI3K/AKT signaling pathway and cancer: an updated review

M Martini, MC De Santis, L Braccini, F Gulluni… - Annals of …, 2014 - Taylor & Francis
… -3-kinase-protein kinase B/AKT (PKB/AKT), p70S6K, and serum- and … Overview of PI3K/AKT/mTOR
signaling pathway. Class I … PI3K-AKT signaling may be antagonized by the tumor …

A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition

W Xu, Z Yang, N Lu - Cell adhesion & migration, 2015 - Taylor & Francis
… Activated Akt will then phosphorylate a series of substrates, … The PI3K/Akt signaling pathway
mediates the process of … strongly related to the PI3K/Akt signaling pathway and the role of …

[HTML][HTML] Research progress on the PI3K/AKT signaling pathway in gynecological cancer

X Shi, J Wang, Y Lei, C Cong… - Molecular medicine …, 2019 - spandidos-publications.com
… using molecular targets in the PI3K/AKT signaling pathway. In brief, the present review
analyzed the effects of the PI3K/AKT signaling pathway on certain gynecological cancer types. …

[HTML][HTML] Targeting PI3K/AKT signaling pathway in obesity

MS Savova, LV Mihaylova, D Tews, M Wabitsch… - Biomedicine & …, 2023 - Elsevier
PI3K/AKT signaling pathway that target obesity management is the main objective of this
review. The PI3K/AKT pathway … the PI3K/AKT signaling is provided. Moreover, druggability of …

PI3k/AKT signaling pathway: Erythropoiesis and beyond

M Jafari, E Ghadami, T Dadkhah… - Journal of cellular …, 2019 - Wiley Online Library
… This process is regulated by several signaling pathways, … PI3K/AKT is one of the most
important pathways that control … In this review, we focus on the role of PI3K/AKT pathway in …

Critical roles of the PI3K/Akt signaling pathway in T cell development

MM Juntilla, GA Koretzky - Immunology letters, 2008 - Elsevier
… However, a complete understanding of the contributions made by the PI3K/Akt pathway in
… the PI3K/Akt pathway is essential for thymocyte survival. We provide new evidence that Akt-…

The PI3K/AKT signaling pathway in cancer: Molecular mechanisms and possible therapeutic interventions

MR Khezri, R Jafari, K Yousefi, NM Zolbanin - Experimental and molecular …, 2022 - Elsevier
… of signaling molecules that regulate PI3K/AKT pathway with … relationship between the PI3K/AKT
signaling pathway and factors … regulating this signaling pathway have been summarized. …

[HTML][HTML] PI3K/AKT/mTOR signaling pathway in breast cancer: from molecular landscape to clinical aspects

D Miricescu, A Totan, II Stanescu-Spinu… - International journal of …, 2020 - mdpi.com
… Currently, clinical studies evaluate inhibitors of the PI3K/AKT/mTOR … AKT signaling pathway,
the factors that activate this protein kinase B, PI3K/AKT-breast cancer mutations, PI3K/AKT/…

[HTML][HTML] Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

C Xue, G Li, J Lu, L Li - Signal transduction and targeted therapy, 2021 - nature.com
… The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway … Emerging data suggest that
the circRNA/PI3K/AKT axis … circRNAs in the circRNA/PI3K/AKT axis is significantly associated …

[HTML][HTML] The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review

K Sun, J Luo, J Guo, X Yao, X Jing, F Guo - Osteoarthritis and cartilage, 2020 - Elsevier
… Based on these reports, we focused on the PI3K/AKT/mTOR signaling pathway and … signaling
pathways. We also present an overview of therapeutic approaches for targeting PI3K/AKT/…