… In conclusion, our results indicate the importance of the PI3K-AKT signaling pathway and
of caspase-3 activity in our AD-iPSCs derived from skin fibroblasts, concerning survival and …

… would block the feedback activation loop of PI3K and Akt and thereby cause a broader
suppression of the PI3K/Akt/mTOR signaling pathway. INK128 is currently being tested in Phase I …

… The PI3K/Akt signaling pathway is involved in cardiovascular … Activation of the PI3K/Akt
pathway provides myocardial protection … Many studies have shown that PI3K/Akt has a significant …

… In summary, the PI3K/AKT/mTOR signaling pathway is a promising targeted approach for
CC treatment and further clinical trials are required. At present, there are ongoing trials with …

… progress in studying roles of PI3K/Akt/mTOR pathway in CaP radiotherapy, and mainly focus
on the effect of single or dual inhibitors targeting this signaling pathway in the treatment of …

… between PI3K/AKT and Raf/MAPK/ERK 1/2 pathways may … We hypothesized that the PI3K/AKT
signal pathway is involved in … intracellular signal pathways, MAPK/ERK 1/2 and PI3K/AKT …

… B/mammalian target of rapamycin (mTOR) signaling pathway, are commonly seen in primary
GBM … , feedback regulation within the mTOR signaling pathway may account for therapeutic …

… In PCa cell proliferation, PI3K activates the AKT/mTOR/p70(S6K) signaling pathway, leading
to G1 cell cycle progression and cyclin expression, then resulting in PCa cell growth (56), …

… signaling cascades JAK2/STAT5, MAPK, and PI3K/AKT that … the MAPK and PI3K/AKT
signaling pathways during red blood … Although the central framework of these pathways is similar …

… , and abnormal activation of this pathway leads to abnormal … Therefore, the PI3K/Akt signaling
pathway is a critical target … that target the PI3K/Akt signaling pathway for the prevention …