Targeting the Akt/PI3K signaling pathway as a potential therapeutic strategy for the treatment of pancreatic cancer
… cer cells through negative modulation of the PI3K/Akt/mTOR signaling pathway [47]. PLB …
of PI3K/Akt/mTOR pathway [85, 86]. Moreover, inhibition of the PI3/ Akt signaling pathway is …
of PI3K/Akt/mTOR pathway [85, 86]. Moreover, inhibition of the PI3/ Akt signaling pathway is …
FUT family mediates the multidrug resistance of human hepatocellular carcinoma via the PI3K/Akt signaling pathway
L Cheng, S Luo, C Jin, H Ma, H Zhou, L Jia - Cell death & disease, 2013 - nature.com
… 3 kinase (PI3K)/Akt signaling pathway and MDR-related protein 1 (MRP1) expression.
Inhibition of the PI3K/Akt pathway by its specific inhibitor wortmannin, or by Akt small interfering …
Inhibition of the PI3K/Akt pathway by its specific inhibitor wortmannin, or by Akt small interfering …
Regulation and importance of the PI3K/Akt/mTOR signaling pathway in hematologic malignancies
K Kawauchi, T Ogasawara, M Yasuyama… - Anti-Cancer Agents …, 2009 - ingentaconnect.com
… Therefore, this pathway is considered a critical target for cancer therapy. We review the
regulatory mechanisms of the PI3K/Akt/mTOR signaling pathway and the role of this pathway in …
regulatory mechanisms of the PI3K/Akt/mTOR signaling pathway and the role of this pathway in …
PIK3CA Mutation H1047R Is Associated with Response to PI3K/AKT/mTOR Signaling Pathway Inhibitors in Early-Phase Clinical Trials
F Janku, JJ Wheler, A Naing, GS Falchook, DS Hong… - Cancer research, 2013 - AACR
… PI3K/AKT/mTOR pathway. Resistance might be determined by the presence of simultaneous
mutations in the mitogen-activated protein kinase (MAPK) pathway … activation of AKT than …
mutations in the mitogen-activated protein kinase (MAPK) pathway … activation of AKT than …
[HTML][HTML] Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway
B Mattioli, L Giordani, MG Quaranta, M Viora - FEBS letters, 2009 - Elsevier
… expression and Akt activation. We found that leptin activates the PI3K-Akt signaling pathway
as … and API-2, which suppress the leptin-induced activation of Akt, NF-kB, bcl-2, bcl-XL and …
as … and API-2, which suppress the leptin-induced activation of Akt, NF-kB, bcl-2, bcl-XL and …
Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway
M Nakayama, J Hisatsune, E Yamasaki… - Journal of biological …, 2009 - ASBMB
… of Akt, … Akt and GSK3β, or release of β-catenin from a GSK3β/β-catenin complex. Taken
together, these results support the conclusion that VacA activates the PI3K/Akt signaling pathway…
together, these results support the conclusion that VacA activates the PI3K/Akt signaling pathway…
Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders
J Chen, I Alberts, X Li - International Journal of Developmental …, 2014 - Elsevier
… -I/PI3K/AKT/mTOR is involved in multiple cell functions, such as protein synthesis, cell survival,
metabolism, etc. This diagram summarizes only IGF-I/PI3K/AKT/mTOR signaling pathway …
metabolism, etc. This diagram summarizes only IGF-I/PI3K/AKT/mTOR signaling pathway …
LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway
H Zhang, Y Pan, M Cheung, M Cao, C Yu, L Chen… - Cell death & …, 2019 - nature.com
… To elucidate whether inhibiting the PI3K/Akt signaling pathway … Inhibition of the PI3K/Akt
signaling pathway significantly … invasion via the PI3K/Akt signaling pathway. LAMB3 knockdown …
signaling pathway significantly … invasion via the PI3K/Akt signaling pathway. LAMB3 knockdown …
Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway
… By using gene expression profiling and bioinformatics analyses, we have proved that the
exosomes can activate the PI3K/Akt signaling pathway, which may be one of the underlying …
exosomes can activate the PI3K/Akt signaling pathway, which may be one of the underlying …
A deregulated PI3K-AKT signaling pathway in patients with colorectal cancer
T Zhang, Y Ma, J Fang, C Liu, L Chen - Journal of Gastrointestinal Cancer, 2019 - Springer
… We validated the PI3K-AKT signaling pathway PCR array results by performing real-time
reverse transcription PCR with paired tumoral and peritumoral tissues from the other subgroups …
reverse transcription PCR with paired tumoral and peritumoral tissues from the other subgroups …