[HTML][HTML] Role and therapeutic targeting of the PI3K/Akt/mTOR signaling pathway in skin cancer: a review of current status and future trends on natural and synthetic …

JC Chamcheu, T Roy, MB Uddin, S Banang-Mbeumi… - Cells, 2019 - mdpi.com
PI3K/Akt/caspase and Fas-L/NF-κB signaling pathways and … of activated mTORC2-Akt-GSK3β
signaling pathway components. … of the PI3K/Akt/mTOR and MAPK signaling pathways. …

[HTML][HTML] PHLDA2 regulates EMT and autophagy in colorectal cancer via the PI3K/AKT signaling pathway

Z Ma, S Lou, Z Jiang - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
pathway in vitro [6]. In addition, PHLDA2 has been shown to activate the PI3K/AKT pathway
… CRC EMT and autophagy through the PI3K/AKT signaling pathway. We also tested the …

Curcumin can improve Parkinson's disease via activating BDNF/PI3k/Akt signaling pathways

T Jin, Y Zhang, BOA Botchway, J Zhang, R Fan… - Food and Chemical …, 2022 - Elsevier
PI3k/Akt signaling pathways in neurodegenerative disease. Here, we summarized the
relationship between BDNF and PI3k/Akt signaling pathway, … and PI3k/Akt signaling pathways in …

Id-1 activation of PI3K/Akt/NFκB signaling pathway and its significance in promoting survival of esophageal cancer cells

B Li, PY Cheung, X Wang, SW Tsao, MT Ling… - …, 2007 - academic.oup.com
… (PI3K)/Akt/ nuclear factor kappa B (NFκB) signaling pathway … We found elevated expression
of phosphorylated forms of Akt… cells confirmed activation of PI3K/Akt/NFκB signaling and the …

Effects of AFP-activated PI3K/Akt signaling pathway on cell proliferation of liver cancer

L Zheng, W Gong, P Liang, XB Huang, N You, KQ Han… - Tumor Biology, 2014 - Springer
… is one of the important intracellular signal transduction pathways, … PI3K/Akt activation. Thus,
we assumed that AFP receptor may be the upstream factor in the PI3K-Akt signaling pathway

Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway

E Fayard, G Xue, A Parcellier, L Bozulic… - … 3-kinase in Health and …, 2011 - Springer
Protein kinase B (PKB/Akt) is a serine/threonine protein kinase that created serious interest
when it was revealed as a mediator of the PI3K pathway. It comprises three isoforms that play …

Targeting the PI3K/Akt signaling pathway in pancreatic β‐cells to enhance their survival and function: an emerging therapeutic strategy for type 1 diabetes

I Camaya, S Donnelly, B O'Brien - Journal of Diabetes, 2022 - Wiley Online Library
… aimed at targeting the PI3K/Akt pathway to prevent/ameliorate … the modulation of the PI3K/Akt
signaling pathway as a novel … the modulation of the PI3K/Akt signaling pathway as a novel …

[HTML][HTML] Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy

B Li, WW Xu, AKY Lam, Y Wang, HF Hu, XY Guan… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… The aim of the study is to identify key signaling pathways that … Gene ontology and pathway
analyses of the differentially … cellular movement and the AKT pathway were associated with …

PI3K/Akt/mTOR signaling pathway and the biphasic effect of arsenic in carcinogenesis

QY Chen, M Costa - Molecular pharmacology, 2018 - ASPET
… Although current studies suggest the mechanisms are manifold, this review focuses
specifically on the role of the PI3K/AKT/mTOR, a prominent cellular signaling pathway, in arsenic-…

Proline-rich Akt substrate of 40 kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway

H Wang, Q Zhang, Q Wen, Y Zheng, P Lazarovici… - Cellular signalling, 2012 - Elsevier
… by Akt phosphorylation, which is part of insulin signal transduction. Therefore, Akt is an
activator of many of the signaling pathways blocked by GSK-3. PI3K activation activates Akt which …