The PI3K-Akt-mTOR and associated signaling pathways as molecular drivers of immune-mediated inflammatory skin diseases: update on therapeutic strategy using …
… of PI3K/Akt/mTOR, underscoring their potential in managing common and persistent skin …
This review summarizes recent advances in understanding the role of the activated PI3K/Akt/…
This review summarizes recent advances in understanding the role of the activated PI3K/Akt/…
[HTML][HTML] Recent updates on the involvement of PI3K/AKT/mTOR molecular cascade in the pathogenesis of hyperproliferative skin disorders
L Mercurio, C Albanesi, S Madonna - Frontiers in medicine, 2021 - frontiersin.org
… impairs keratinocyte differentiation in skin affected by psoriasis (21). The role of PI3K/AKT/mTOR
in … AD is an immune-mediated skin disease characterized by alterations of skin barrier …
in … AD is an immune-mediated skin disease characterized by alterations of skin barrier …
The PI3K/Akt pathway: emerging roles in skin homeostasis and a group of non-malignant skin disorders
Y Teng, Y Fan, J Ma, W Lu, N Liu, Y Chen, W Pan… - Cells, 2021 - mdpi.com
… Acne vulgaris is a common recurrent inflammatory skin disease with a complicated mechanism
[86,87]. The major hormones like androgens, insulin, and insulin-like growth factor-1(IGF-…
[86,87]. The major hormones like androgens, insulin, and insulin-like growth factor-1(IGF-…
The role of PI3K/AKT/FOXO signaling in psoriasis
M Zhang, X Zhang - Archives of Dermatological Research, 2019 - Springer
… its clinical relevance in inflammatory diseases, including psoriasis [24, 25, 54]. PI3K/AKT
axis has vital function in inflammatory skin diseases, especially its downstream signaling target …
axis has vital function in inflammatory skin diseases, especially its downstream signaling target …
Role and therapeutic targeting of the PI3K/Akt/mTOR signaling pathway in skin cancer: a review of current status and future trends on natural and synthetic agents …
… view of treating various cutaneous diseases including cancers [40,41,42]. Undesirable effects
of UV rays in skin include allergic and inflammatory diseases, immunosuppression, photo-…
of UV rays in skin include allergic and inflammatory diseases, immunosuppression, photo-…
Rhododendrin ameliorates skin inflammation through inhibition of NF-κB, MAPK, and PI3K/Akt signaling
YJ Jeon, BH Kim, S Kim, I Oh, S Lee, J Shin… - European journal of …, 2013 - Elsevier
… that rhododendrin is a biologically active compound that exhibits anti-inflammatory activity
and is a promising candidate molecule to treat inflammatory skin diseases, such as psoriasis. …
and is a promising candidate molecule to treat inflammatory skin diseases, such as psoriasis. …
LncRNA MEG3 suppresses PI3K/AKT/mTOR signalling pathway to enhance autophagy and inhibit inflammation in TNF-α-treated keratinocytes and psoriatic mice
ZL Tang, K Zhang, SC Lv, GW Xu, JF Zhang, HY Jia - Cytokine, 2021 - Elsevier
… in cells and skin tissues respectively. LY294002 was used to block the PI3K/AKT/mTOR
signalling. … responses in several diseases [14], [15], [16]. Recent studies also reported that the …
signalling. … responses in several diseases [14], [15], [16]. Recent studies also reported that the …
… Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease …
… and PI3K kinase activities, thereby attenuating Akt activation … of the PI3K/Akt/mTOR components
in inflamed skin lesions of … psoriasis-like skin model compared with healthy skin (7, 22). …
in inflamed skin lesions of … psoriasis-like skin model compared with healthy skin (7, 22). …
[HTML][HTML] Molecular genetics of the PI3K-AKT-mTOR pathway in genodermatoses: diagnostic implications and treatment opportunities
… PI3K-AKT-mTOR pathway consisting of a cascade of inhibitor/activator molecules. Recently,
a number of heritable diseases with skin … the genes in the PI3K-AKT-mTOR and interacting …
a number of heritable diseases with skin … the genes in the PI3K-AKT-mTOR and interacting …
… induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice
J Gao, J Guo, Y Nong, W Mo, H Fang, J Mi, Q Qi… - BMC Pharmacology and …, 2020 - Springer
… Psoriasis is a chronic inflammatory skin disease affecting 2–3% of the population worldwide.
Hyperproliferative keratinocytes were thought to be an amplifier of inflammatory response, …
Hyperproliferative keratinocytes were thought to be an amplifier of inflammatory response, …