… PI3K and are present in a subset of pancreatic cancers. Here we examine mutant PIK3CA-…
pancreatic tumorigenesis and the response of PIK3CA mutant pancreatic cancers to dual PI3K/…

… to be critical for tumorigenesis in other … pancreatic tumorigenesis using isoform-specific
knockout mice. We show that the p110α catalytic subunit is required for pancreatic tumorigenesis …

… expressing this mutant form within their pancreas [18]. PDAC … pancreatic tumorigenesis.
Attempts to target critical Ras effectors revealed a heavy dependency of K-Ras on the PI3K …

… The literature clearly demonstrates that PI3K/Akt axis is deeply involved in the transdifferentiation
process of the pancreas occurring during pancreatic carcinogenesis. The relationship …

… , the gene encoding PI3K, have been reported in a subset of pancreatic cancer precursors,
… mutations, the PI3K/AKT pathway is constitutively active in the majority of pancreatic cancers […

… cancers possess PIK3CA mutations, which lead to oncogenic activation of the PI3K …
pancreatic tumorigenesis and the response of PIK3CA-mutant PDAs to dual PI3K/mTOR inhibition. …

… Constitutive activation of PI3K leads to pancreatic carcinogenesis in vivo. (A) Pancreases
from KC (n = 5) and KC/p110α CA (n = 3) mice were evaluated by hematoxylin and eosin (H&E…

… the role of PI3K regulation of RAC1 for KRAS-induced pancreatic tumorigenesis in mice [42].
It … /ERK signaling cascade in pancreatic cancer which is responsible for resistance to PI3K …

… pharmacological isoform-selective inhibitors, we found that the p110α PI3K isoform is a major
… In tissue other than the pancreas, Pten deletion-induced tumorigenesis was shown to be …

… Furthermore, in vitro and in vivo studies were performed to determine whether miR-23b-3p
promotes PC cell tumorigenesis and metastasis by activating the JAK/PI3K and Akt/NF-κB …