… kinase activity within cells and acute brain tissue, we reveal that the inflammation associated
kinase, protein kinase R (PKR… -modifying residues within tau including Thr181, Ser199/202, …

… Our morphological data showed that the phosphorylated form of PKR, GSK-3β or tau
protein can be co-expressed in the brains of AD patients, suggesting a possible molecular …

… reports implicating the kinase PKR in the pathogenesis of the … PKR and tau detected in AD
brains and could implicate PKR … the reasons why PKR gene expression is differently regulated …

… initiation factor 2 α (eIF2α) kinase II (PKR) in brain cells and leading … PKR is a ubiquitously
expressed serine–threonine protein … PKR and p38 inhibitors could also reduce abnormal tau …

… This review is focused on the kinase PKR and the … Furthermore, this PKR-mediated
phosphorylation induces tau … of PKR or the expression of a dominant-negative form of PKR inhibits …

… RNA-dependent protein kinase PKR is well known as an … tau through activation of PKR and
downstream stress activated … changes in kinase expression and kinase activation (51). Active …

… can phosphorylate tau protein via GSK3β kinase activation. … able to trigger PACT protein
expression and PKR activation, we can … PACT accumulation and leading to tau phosphorylation. …

… In contrast to nondemented controls, AD cases showed prominent granular phospho-PKR …
-PKR matched the distributions of abnormally phosphorylated tau and active p38 MAP kinase …

… was co-expressed with phosphorylated tau in AD brains and … synthase kinase 3β activation
and tau phosphorylation (25). … kinase PKR can control indirectly the phosphorylation of tau …

… , PKR and eIF2 levels were adjusted to -actin expression. … positively correlated with total tau
and p-tau. This suggested … translation of tau mRNA, contributing to hyperphosphorylated tau …