… Membranous nephropathy (MN) is a unique glomerular … podocyte membrane antigen PLA2R
(70%), biopsy evidence PLA2R … anti-PLA2R/THSd7A antibody or antigen likely have PMN …

… Primary membranous nephropathy (MN) is an autoimmune … antigens: the M-type phospholipase
A2 receptor 1 (PLA2R) … Assays for quantitative assessment of anti-PLA2R antibodies …

… bind to an intrinsic antigen on glomerular podocytes and … target antigen, the M-type
phospholipase A 2 receptor 1 (PLA 2 R)… anti-PLA 2 R and tissue staining for the redistributed …

… Antibodies to the phospholipase A2 receptor 1 (PLA2R1) have been reported in 70% of cases
of idiopathic membranous nephropathy (… retrospectively quantified PLA2R antibodies by …

… the expression of PLA2R in glomeruli. … -PLA2R antibodies or enhanced expression of
PLA2R were found in podocytes; however, we could detect autoantibodies and enhanced PLA2R …

… We detected PLA 2 R by using guinea pig anti-PLA 2 R antibodies (at a dilution of 1:150),
followed by a Cy3-conjugated secondary antibody (see the Supplementary Appendix), and …

… In the secondary MN cases that we have tested, the PLA2R antigen did not colocalize with
IgG in the immune deposits, but was rather still present in the podocyte cell body as in normal …

… for circulating anti-PLA2R antibodies despite PLA2R antigen positivity in the … were PLA2R
positive while PLA2R antigen was found in 22 of the 37 (59%) corresponding biopsies. PLA2R …

… presence of the PLA2R antigen in glomeruli of patients without anti-PLA2R serum reactivity …
that renal PLA2R staining increases the sensitivity for the diagnosis of PLA2R-related MN. …

… (PLA 2 R) was recently identified as a major target antigen involved in idiopathic membranous
nephropathy in … Circulating autoantibodies against PLA 2 R were found in 70 to 80% of …