… We assumed that “morphine concentration” was the concentration of morphine base and
not that of the morphine salt. This may have been incorrect for some studies, but without …

… In the present paper the effects of age and various other factors are investigated with respect
to morphine requirements and plasma concentrations. With a study group of 200 infants, …

… in postoperative therapeutic plasma concentrations for only 1 … relationship between plasma
concentrations of morphine and … may therefore require a higher rectal dose of morphine and …

… This investigation sought to define a possible correlation between morphine dosing rates
and time of day by examining diurnal variations in analgesic dosing requirements in both “…

… in the treatment of cancer pain is thata very wide range of doses may be required and the …
morphine in early studies and it is also important to consider that plasma concentrations are …

… If required, the patients were given other narcotic analgesics during the study. … plasma
concentration of albumin or orosomucoid (Table II), which would have been expected if plasma …

… requirements of morphine, so that the process of dosage individualisation is an important
aspect in the clinical use of the drug. Much of this inter-patient variability is explained by large …

… present study were to observe plasma concentration distributions of morphine, M3G, and M6G
in … The dose of morphine required for adequate pain relief varies greatly between patients; …

… of morphine. Further studies investigating the relationship between plasma concentrations of
morphine… appearance and magnitude of side effects during morphine therapy are required. …

… to the plasma concentration, which is often used as a proxy for the concentration at effect-site. …
In PK non-steady state conditions, when drug concentration in plasma and effect-site is not …