Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles

MA Dobrovolskaia, AK Patri, J Zheng… - … , Biology and Medicine, 2009 - Elsevier
plasma protein) on 30- and 50-nm colloidal gold particles in our in vitro study. Fibrinogen
is composed of α, β, and γ chains, and it has an elongated configuration in comparison to …

Protein corona composition does not accurately predict hematocompatibility of colloidal gold nanoparticles

MA Dobrovolskaia, BW Neun, S Man, X Ye… - … , Biology and Medicine, 2014 - Elsevier
nanoparticle surface properties (PEGylation) and incubation times on the protein coronas of
colloidal gold nanoparticles. … Therefore, we examined the kinetics of plasma protein binding …

Protein corona formed from different blood plasma proteins affects the colloidal stability of nanoparticles differently

YT Ho, NA Azman, FWY Loh, GKT Ong… - Bioconjugate …, 2018 - ACS Publications
… Furthermore, the unique aggregation profile of different plasma proteins used in our study
also suggested possible use of NP aggregation as a technique to identify and characterize …

Interaction of gold nanoparticles with common human blood proteins

SHDP Lacerda, JJ Park, C Meuse, D Pristinski… - ACS …, 2010 - ACS Publications
… toxic response that can result from environmental exposure to NP, we focus on the adsorption
of common plasma proteins on model gold NPs. We emphasize the quantification of the …

Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses

ZJ Deng, M Liang, I Toth, M Monteiro, RF Minchin - Nanotoxicology, 2013 - Taylor & Francis
… of nanoparticles in the body. We examined plasma protein binding to gold nanoparticles (5–…
Positively and negatively charged nanoparticles bound a range of proteins whereas neutral …

Synthesis, capping and binding of colloidal gold nanoparticles to proteins

THL Nghiem, TH La, XH Vu, VH Chu… - Advances in Natural …, 2010 - iopscience.iop.org
… and biofunctionalized layer for water-dispersed gold nanoparticles (NPs) synthesized from
metal precursor HAuCl 4 . The BSA binding to gold NPs was characterized qualitatively and …

Blood protein coating of gold nanoparticles as potential tool for organ targeting

M Schäffler, F Sousa, A Wenk, L Sitia, S Hirn, C Schleh… - Biomaterials, 2014 - Elsevier
Protein gold nanoparticle conjugate … Hence, we conclude that both, protein conjugation
and the NP size have a significant influence on biodistribution of nanoparticles in the body. …

High-throughput screening using the surface plasmon resonance effect of colloidal gold nanoparticles

P Englebienne, A Van Hoonacker, M Verhas - Analyst, 2001 - pubs.rsc.org
… and extensively used for the study of drug-plasma protein interactions, 12 but is not useful
for high-… Colloidal gold has been recently proposed as an interesting alternative support for …

Gold nanoparticles: role of size and surface chemistry on blood protein adsorption

F Benetti, M Fedel, L Minati, G Speranza… - Journal of nanoparticle …, 2013 - Springer
… In the present study, two of the most abundant plasma proteins, HSA and Fng, were considered,
due to their fundamental role in coagulation and homeostasis. In particular, HSA is the …

Component‐specific analysis of plasma protein corona formation on gold nanoparticles using multiplexed surface plasmon resonance

A Patra, T Ding, G Engudar, Y Wang, MM Dykas… - Small, 2016 - Wiley Online Library
… and pharmacodynamics of circulating nanoparticles. Here, for the first time… proteins (human
serum albumin, fibrinogen, ApoA1, and polyclonal IgG) are determined for gold nanoparticles