… functional genetic validation of P. falciparum DXR (PF14_0641). Using a single cross-over
strategy, we show that plasmid integration occurs at the DXR locus but only when DXR gene …

… whether the enzymes encoded by those genes in P. falciparum will In all organisms studied
so far, the biosynthesis of isoprenoids decatalyze the same reactions as demonstrated for …

… falciparum genome, but only three genes that encode the enzymes DOXP synthase, DOXP
reductoisomerase and 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase have been …

… The MEP pathway is essential in key human pathogens, including Plasmodium falciparum
malarial parasites and the bacterium Mycobacterium tuberculosis, and in many Gram-…

… phosphate reductoisomerase (IspC) of Plasmodium falciparum and for their in vitro antiplasmodial
activity against chloroquine-sensitive and resistant strains of P. … falciparum the genetic …

… the DOXP reductoisomerase gene is highly conservation among multidrug resistant P.
faciparum … of the DOXP reductoisomerase gene among multidrug resistant P. faciparum isolates …

… with a single species, Plasmodium falciparum, although P. vivax and P. knowlesi have also
… an enormous technical advance in genetic studies of nonmodel organisms, including P. …

… Fosmidomycin has been proven to be efficient in the treatment of P. falciparum malaria by
inhibiting 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), an enzyme of the non-…

… lavendulae, was found to inhibit DOXP reductoisomerase, the second enzyme of the …
Due to the high A/T content of the P. falciparum genome fully synthetic genes adapted to the …

… biosynthesis present in Plasmodium falciparum was shown to … The presence of two genes
encoding the enzymes DOXP … complete gene encoding the DOXP reductoisomerase of P. …