Tissue regeneration and in loco administration of platelet derivatives: clinical outcome, heterogeneous products, and heterogeneity of the effector mechanisms

P Borzini, L Mazzucco - Transfusion, 2005 - Wiley Online Library
… Appreciable effects have been obtained by in loco administration of platelet (PLT)
derivatives such as PLT gel, PLT-rich plasma (PRP), and similar products to treat tissue lesions. …

Platelet‐rich plasma (PRP) and platelet derivatives for topical therapy. What is true from the biologic view point?

P Borzini, I Mazzucco - ISBT Science Series, 2007 - Wiley Online Library
products which, in turn, have distinct biological properties and healing … Heterogeneity is
conceived for platelet concentration; white blood cells or buffy-coat inclusion in the product; kind, …

[HTML][HTML] In vitro evidence supporting applications of platelet derivatives in regenerative medicine

I Giusti, S D'Ascenzo, G Macchiarelli, V Dolo - Blood Transfusion, 2020 - ncbi.nlm.nih.gov
platelet derivatives on a wide variety of human cells, highlighting their possible impact for in
vivo applications. The heterogeneity … the composition of platelet derivatives and the method …

Blood derivatives awaken in regenerative medicine strategies to modulate wound healing

BB Mendes, M Gómez-Florit, PS Babo… - Advanced drug delivery …, 2018 - Elsevier
derivatives rich in platelets. Finally, we discussed possible directions for biomaterials design
to potentiate the aimed regenerative effects of blood derivatives … , the heterogeneity among …

Immunoregulatory role of platelet derivatives in the macrophage-mediated immune response

E Anitua, M Troya, MH Alkhraisat - Frontiers in Immunology, 2024 - frontiersin.org
… standardization for these platelets products leads to multiple … resulting in biologically
heterogeneous final products (51, 52) … on the effects of platelet derivatives on the phenotype and …

Platelets and platelet-inspired biomaterials technologies in wound healing applications

UDS Sekhon, A Sen Gupta - ACS Biomaterials Science & …, 2017 - ACS Publications
… Figure 6 shows examples of beneficial effects of platelet lysate derivatives (eg, platelet
lysate gel) on augmenting angiogenic and proliferative outcomes in wound healing models in …

Overview of platelet physiology: its hemostatic and nonhemostatic role in disease pathogenesis

K Ghoshal, M Bhattacharyya - The Scientific World Journal, 2014 - Wiley Online Library
Platelets activation and dysfunction have been implicated in diabetes, renal diseases, …
that platelets are not that innocent as they keep showing and thus numerous novel platelet

N-Substituted indole carbohydrazide derivatives: synthesis and evaluation of their antiplatelet aggregation activity

SS Mirfazli, F Kobarfard, L Firoozpour… - DARU Journal of …, 2014 - Springer
… most potent derivatives of the 2-substituted indole on plateletplatelet aggregation pathway
is very complex and involves multiple components and it can be controlled by heterogeneous

A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.

A Hammacher, U Hellman, A Johnsson… - Journal of Biological …, 1988 - ASBMB
… PDGF was first purified from human platelets (15-18). The purified product contains A and
B … structure of PDGF due to the extensive heterogeneity of the factor, caused by proteolysis …

An overview of platelet products (PRP, PRGF, PRF, etc.) in the Iranian studies

SA Raeissadat, M Babaee, SM Rayegani… - Future science …, 2017 - Taylor & Francis
platelets and their derivatives in Iran, we elected to survey the existing published research by
Iranian researchers on various platelet products in … To the same extent, the heterogeneous