… clopidogrel metabolites, we referred to the largest study by Mega et al. For studies of CYP2C19
genotype and platelet function… platelet function measure in different genotype categories. …

… clopidogrel. To reflect a patient's full response to clopidogrel, only those patients whose initial
platelet function … Platelet function was assessed at multiple time points in different patients …

… enzymes involved in the metabolism of clopidogrel. However, the … that clopidogrel was
converted into 2-oxo-clopidogrel by … metabolism in vitro and that hydrolysis of 2-oxo-clopidogrel …

… In conclusion, comparing the metabolic profiles of prasugrel and clopidogrel offers 3 relevant
findings. First, the coadministration of prasugrel with other drugs is less likely to result in …

… as absorption and/or metabolism, may account for the differences between prasugrel and …
, and consistent inhibition of platelet function than does the approved clopidogrel 300 mg LD …

… Areas covered in this review: This review compares the metabolism of clopidogrel and …
prasugrel and clopidogrel and how the differences in their respective metabolic pathways explain …

… metabolism of clopidogrel to the thiol acid active metabolite, namely, that it is oxidized to 2-oxo-clopidogrel …
on this topic that concluded that platelet function studies do not demonstrate a …

… In contrast, in genetically engineered human microsomes containing a single human P450
isoenzyme, CYP3A4 and 3A5 appear primarily responsible for clopidogrel metabolism. The …

… , the anti-platelet function of clopidogrel is … metabolic route of clopidogrel is its metabolism
by esterase to the inactive metabolite (SR26334) and the active metabolism of clopidogrel by …

… polymorphisms of the CYP2C19 gene (such as CYP2C19 * 2 and CYP2C19 * 3) have been
associated with a reduced clopidogrel metabolism and a lessening of clopidogrel effect. As …