… Clopidogrel is a prodrug, which needs to be metabolized in the … clopidogrel with routinely
used platelet function methods, which are widely available and accepted. The platelet function …

… Consistent with other studies, we found that platelet reactivity was higher in clopidogrel-treated
patients receiving proton pump inhibitors compared with those not receiving proton pump …

… The present study is the first to demonstrate that, despite having reduced clopidogrel
metabolism, most carriers of the loss-of-function CYP2C19*2polymorphism can reach optimal PRI …

… , and interindividual differences in clopidogrel metabolism are a … critical role in the metabolism
of clopidogrel. Multiple studies … tailoring clopidogrel therapy using platelet function testing …

… clopidogrel is a prodrug that requires activation by cytochrome P450 isoenzymes before
it can inhibit platelet function… isoenzymes involved in clopidogrel metabolic activation (CYP2C19…

… to DDIs involving clopidogrel may include [Citation8]: 1) drugs acting as CYP2C19 and
CYP3A4 inhibitors thus blocking the metabolic pathway of clopidogrel as a victim; 2) clopidogrel …

… reactivity of resting platelets, dysfunctional cytochrome P450 metabolism (either because of
… /collagen-coated cartridges in a platelet function analyzer. This observation is in agreement …

… As hypothesized by others (32), our data confirm that platelet function tests might produce
… [Citation55] and minimal changes in clopidogrel metabolism might result in a more unstable …

… – about 85–90% of total clopidogrel is metabolized by this pathway. This conversion … as
clopidogrel and prasugrel, for the enzyme. Reduced inhibition of platelet function by clopidogrel …

… Clopidogrel has significantly reduced the incidence of … platelet inhibition by standard
clopidogrel therapy. Genetic polymorphisms involved in clopidogrel’s absorption, metabolism, and …