25 天前 - … Citation1 Clopidogrel is a prodrug that requires bioactivation into … metabolic activity
of CYP2C19 significantly affects the pharmacokinetics of clopidogrel by altering its metabolic …

56 天前 - … and the remaining 15% is rapidly metabolized in a two-step … CYP2C19 plays a major
role in clopidogrel metabolism in … combing genetic testing with platelet function testing and …

62 天前 - … genomic variants that affect clopidogrel metabolism exist. We … platelet function
analysis were collected at a single time point on the day of recruitment while under clopidogrel …

74 天前 - … CYP2C19 influences clopidogrel metabolism and … clopidogrel resistance in India
ranges from 5 to 44 %. By selecting antiplatelet therapy based on the patient's platelet function …

99 天前 - … to contribute to clopidogrel metabolism and disposition, … to have high platelet
reactivity while on clopidogrel. In … of clopidogrel resistance, as measured by platelet functional …

105 天前 - … Understanding the mechanisms controlling platelet function is crucial for exploring
… 12 receptor inhibitors (clopidogrel, prasugrel, among others) to block platelet activation and …

106 天前 - … extensive metabolic phenotype. In conclusion, PON1 rs854552 polymorphisms
may affect clopidogrel response. Bioinformatics prediction followed by functional validation …

106 天前 - … a COX-1 inhibitor, and clopidogrel and prasugrel, both of … For example,
unresponsiveness to clopidogrel has been … 1 and platelet function, inflammation and metabolic …

118 天前 - … is associated with poor clopidogrel metabolism, in turn leading to … platelet function
and genetic testing. Five major studies have assessed the impact of PFT to guide clopidogrel …

133 天前 - … , gain-of-function (GoF)] clopidogrel metabolism.(5) While … 21 Platelet function may
be assessed by different assays, … , low platelet reactivity (LPR) or optimal range of platelet …