… sum of the number of risk alleles an … polygenic risk scores may be informative at different
points in the disease trajectory, from unaffected individuals being tested for future disease risk to …

… is broken down by polygenic risk score (PRS) tier (top quintile, middle three quintiles (from
the 20th to the 80th percentile) and bottom quintile of genetic risk). The underlying data are …

… Polygenic risk scores for an individual are calculated as weighted counts of thousands of risk
variants that they carry, where the risk variants … Observations Polygenic risk scores can be …

… predictive accuracy of a polygenic score are derived from a … in the score, and methods for
weighting effect sizes in the score. … significant association of polygenic scores have been well …

A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual’s
genetic liability to a trait or disease, calculated according to their genotype profile and relevant …

… polygenic risk score may augment the risk conferred by a high-impact mutation, or a protective
polygenic risk score … and bring the individual’s risk closer to the population average 7 . …

… genomic information into risk models. Polygenic risk scores (PRS) aggregate the effects of
many genetic variants across the human genome into a single score and have recently been …

Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibility to diseases,
calculated for individuals as weighted counts of thousands of risk variants in which the …

… about polygenic risk score usage among diverse populations, summarized in four key
points. First, polygenic scoring … Second, the performance of polygenic scores in non-European …

… outcomes, this polygenic effect can be considered a genetic liability to disease risk. While …
by this polygenicity, the application of polygenic risk scores (PRS) has shown that prediction is …