… each polyQ disease, the … posttranslational modifications that regulate polyQ toxicity. We
conclude by discussing shared processes and pathways that bring some of the polyQ diseases …

… of function mechanisms, the clearance of the disease-causing proteins is key to fight the …
that post-translational modifications (PTMs) of proteins linked to neurodegenerative diseases …

… Polyglutamine diseases are a family of nine … post-translational events may also be crucial
for pathogenesis. Here, we review how post-translational modifications of the polyglutamine …

… and post-translational dysregulation in polyQ diseases. We … in polyQ diseases and further
discuss the role of post-translational … ’s disease (HD), which is the best-known polyQ disease. …

… disorders. Polyglutamine diseases are a large group of inherited neurodegenerative …
Post-translational modifications involved in the modulation of polyQ protein aggregation are …

… disease process. This review examines the fate of mutant protein in neurons and the potential
… of posttranslational events in pathogenesis, with particular focus on the polygln diseases. …

… The chemical modifications of proteins during or after their biosynthesis via the covalent …
amino acids are collectively termed protein post-translational modifications (PTMs). PTMs can …

… of a polyglutamine repeat. The mechanism of pathogenesis is still not fully characterized;
however, evidence suggests that post-translational modifications (… of mutant polyglutamine-…

… context and post-translational modifications on aggregation, and a potential role for lipid
membranes in aggregation. As the pathogenic mechanisms that underlie these disorders are …

… Other modifications, such as phosphorylation, are common mechanisms underlying the …
’s disease (HD) is a neurodegenerative disease caused by an expanded polyglutamine (polyQ) …