… that the protein context of the polyQ tract has an essential role in the … role of protein context
in modulating the polyQ diseases and the therapeutic potential of targeting non-polyQ protein …

… tract facilitates a crucial conformational transition, which can be influenced by numerous
factors, including the protein context of the repeats and intracellular protein interactions. …

… of the function of the full-length protein, and (2) a … polyglutamine tract itself regardless of
the protein context in which it is located. In the first case, the altered toxic function of the protein …

… protein context within which it resides. Nevertheless, the protein context does modulate
polyglutamine … For instance, although aggregates of all polyglutamine disease proteins will …

… , indicate that host protein context is the key arbiter of polyglutamine disease protein toxicity.
… of nuclear inclusions or the propensity of polyglutamine to aggregate. Indeed, an intimate …

… disease process; next, it will be necessary to explain how specific changes in disease
proteins … they override their specific disease context, causing a more widespread “glutaminopathy.” …

… and this work was on a model protein and not on a polyglutamine disease causing protein.
We used time-… have similar toxic structures despite the context of their amino acids sequence. …

… the production of proteins with expanded polyglutamine (PolyQ) stretch. The expression of
these pathogenic proteins leads to PolyQ diseases, such as Huntington’s disease or several …

… context of the full-length proteins, as implied by variations in the length of the polyQ tract
required to trigger the onset of a given polyQ disease. … Polyglutamine diseases are a large group …

… depends on protein context. These curves imply that in this class of inherited neurodegenerative
… on the protein in which it is contained. Most patients with polyglutamine diseases are …