Polynucleotide phosphorylase independently controls virulence factor expression levels and export in Yersinia spp.

JA Rosenzweig, B Chromy, A Echeverry… - FEMS microbiology …, 2007 - academic.oup.com
… assays requires the exoribonuclease polynucleotide phosphorylase (PNPase) and that …
-binding domain of PNPase. Here, it is shown that the YersiniaΔpnp strain is less virulent in the …

Polynucleotide Phosphorylase Regulates Multiple Virulence Factors and the Stabilities of Small RNAs RsmY/Z in Pseudomonas aeruginosa

R Chen, Y Weng, F Zhu, Y Jin, C Liu, X Pan… - Frontiers in …, 2016 - frontiersin.org
… revealed a pleiotropic role of PNPase in gene regulation. … the roles of PNPase in the regulation
of virulence factors and … KH-S1 domains of PNPase and the virulence factors as well as …

The exoribonuclease polynucleotide phosphorylase influences the virulence and stress responses of yersiniae and many other pathogens

JA Rosenzweig, AK Chopra - Frontiers in cellular and infection …, 2013 - frontiersin.org
… on the presence of an exoribonuclease, polynucleotide phosphorylase (PNPase). PNPase
has also been implicated as a virulence factor in several notable pathogens including the …

Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica

MO Clements, S Eriksson… - Proceedings of the …, 2002 - National Acad Sciences
virulence factors (… polynucleotide phosphorylase (PNPase) and chronic infection while
characterizing a mutant of Salmonella typhimurium that was defective in its expression of virulence

Polynucleotide Phosphorylase Negatively Controls spv Virulence Gene Expression in Salmonella enterica

SE Ygberg, MO Clements, A Rytkönen… - Infection and …, 2006 - Am Soc Microbiol
PNPase, the growth conditions applied were not optimal for the expression of several virulence
… To further define the repertoire of virulence genes affected by PNPase, we extended the …

Defects in polynucleotide phosphorylase impairs virulence in Escherichia coli O157:H7

J Hu, MJ Zhu - Frontiers in microbiology, 2015 - frontiersin.org
… ) is reported to regulate virulence in Salmonella, Yersinia sp. and Campylobacter jejuni, yet
… :H7 virulence, pnp deletion mutants were generated and the major virulence factors were …

CvfA protein and polynucleotide phosphorylase act in an opposing manner to regulate Staphylococcus aureus virulence

S Numata, M Nagata, H Mao, K Sekimizu… - Journal of Biological …, 2014 - ASBMB
… aureus virulence factor using a … polynucleotide phosphorylase (PNPase) with 3′- to 5′-exonuclease
activity. The suppression was blocked by introducing a pnpA-encoding PNPase

Neisseria meningitidis polynucleotide phosphorylase affects aggregation, adhesion, and virulence

J Engman, A Negrea, S Sigurlásdóttir… - Infection and …, 2016 - Am Soc Microbiol
… Deletion of PNPase led to global transcriptional changes and … PNPase is required for full
virulence in an in vivo model of N. meningitidis infection. The present study shows that PNPase

Polynucleotide phosphorylase and the T3SS

JA Rosenzweig, K Schesser - The Genus Yersinia: From Genomics to …, 2007 - Springer
… We have shown that PNPase also enhances the ability of Yersinia to withstand the killing …
identified another such factor, the exoribonuclease polynucleotide phosphorylase (PNPase) as …

Ribonucleases and bacterial virulence

A Lawal, O Jejelowo, AK Chopra… - Microbial …, 2011 - Wiley Online Library
… and include the exo-ribonuclease polynucleotide phosphorylase (PNPase), a DEAD box (…
pyogenes, PNPase was found to target specific virulence factor encoding transcripts, sagA (…