Rationale and design of a randomized controlled trial of pneumococcal polysaccharide vaccine for prevention of cardiovascular events: the Australian Study for the …

S Ren, A Hure, R Peel, C D'Este, W Abhayaratna… - American heart …, 2016 - Elsevier
… ) to be conducted to test whether vaccination with the pneumococcal polysaccharide vaccine
will reduce cardiovascular events. If successful, vaccination can be readily extended to at-…

Rational design of conjugate vaccines

RZ Dintzis - Pediatric research, 1992 - nature.com
… in children vaccinated with type b polysaccharide vaccine. N … b polysaccharide-outer
membrane protein conjugate vaccine … previous vaccination with type b polysaccharide vaccine. J …

… controlled effectiveness evaluation to accelerate the introduction of Vi polysaccharide typhoid vaccine in developing countries in Asia: rationale and design

CJ Acosta, CM Galindo, M Ali… - Tropical Medicine & …, 2005 - Wiley Online Library
… Here we describe the rationale and design behind the … Vi polysaccharide (PS) vaccine
and present preliminary results of the pilot phase that guided decisions in the final study design

[PDF][PDF] Rationale and design of CAPITA: a RCT of 13-valent conjugated pneumococcal vaccine efficacy among older adults

E Hak, DE Grobbee, EA Sanders, TJ Verheij… - Neth J Med, 2008 - academia.edu
… Although the 23-valent polysaccharide pneumococcal vaccine (23vPs) is considered
effective in the prevention of invasive pneumococcal disease in the elderly population, the …

Polysaccharide vaccines

R Austrian - Annales de l'Institut Pasteur/Microbiologie, 1985 - Elsevier
… of the failure of many to perceive that the aggregate efficacy ef a vaccine designed to
prevent 23 immunologieally distinct infections is unlikely ever to equal that of a monovalent …

Polysaccharides and glycoconjugates as human vaccines

HJ Jennings, RA Pon - Polysaccharides in medicinal applications, 2017 - taylorfrancis.com
polysaccharides, and this led to the formulation of a 23-valent polysaccharide vaccine which
remains the current vaccine … of the polysaccharides used in the current vaccine are shown …

[PDF][PDF] Vaccine technologies & the rationale for new nanoparticle formulations

RS Becker - Drug Development & Delivery, 2014 - lubrizolcdmo.com
… The liposomes have been designed in some applications to contain and deliver vaccine
antigen-specific B lymphocytes a means to bind the polysaccharide via their antibody and …

Vaccine design in the 21st century

MJ Bottomley, R Rappuoli, O Finco - The vaccine book, 2016 - Elsevier
… Such vaccines were based on the use of capsular polysaccharide (CPS) preparations …
underlying polysaccharide vaccine-induced immunity. However, plain polysaccharide vaccines …

Mucosal vaccine design and delivery

KA Woodrow, KM Bennett, DD Lo - Annual review of biomedical …, 2012 - annualreviews.org
… For example, the meningococcal unconjugated polysaccharide vaccine given in young
children leads to a significant ELISA-detectable antibody binding response but provides poor …

Capsular polysaccharides as vaccine candidates

HJ Jennings - Bacterial Capsules, 1990 - Springer
… A promising area of research to overcome the deficiency of polysaccharide vaccines in
infants is the design of a new generation of semisynthetic vaccines based on the conjugation (…