… Kinase alterations identified in patients with Philadelphia chromosome (Ph) –like acute
lymphoblastic leukemia (ALL). Data are shown for 86 patients with Ph-like ALL who underwent …

… can also confer a poor prognosis 4 ; of these, the chromosomal translocation t(9;22) is … of
the Philadelphia chromosome; patients who were negative for the chromosome at diagnosis but …

… poor outcome in Ph-positive adult ALL. In this study, we analyzed the clinical characteristics
and outcome of 67 adults with Ph-… In this analysis, the Ph chromosome was identified in 13% …

… Ph chromosome appears to be an independent adverse risk factor for children with ALL 3-5.
Indeed, despite favorable outcomes … the EFS outcome was poor for the overall group of Ph+ …

… Poor treatment outcome of Philadelphia chromosome-positive pediatric acute
lymphoblastic leukemia despite intensive chemotherapy. Leuk Lymph 1999; 345: 998–1006. …

BACKGROUND Up to 5% of patients with chronic myelogenous leukemia (CML) do not have
the Philadelphia (Ph) translocation t(9;22)(q34;q11) or a bcr/abl molecular rearrangement. …

… additionally worsens the outcome. Another major reason for the poor outcome in elderly …
factors, particularly the increasing frequency of Philadelphia chromosome-positive (Phþ) ALL …

… In 1970, the Ph chromosome was first reported in a patient with ALL (12). The Ph chromosome
is … benefit patients with poor prognostic factors, such as the Ph chromosome (24,25). of the …

… The Philadelphia chromosome (Ph) is the most common cytogenetic abnormality … (TKIs),
Ph-positive ALL carried a dismal prognosis and was characterized by a poor response to most …

… Even though Ph-like ALL is associated with poor outcome, given the heterogeneity of treatment
response, we recommend MRD-directed treatment to avoid over- or undertreatment and …