Population genomics of cardiometabolic traits: design of the university college london-london school of hygiene and tropical medicine-edinburgh-bristol (UCLEB) …

T Shah, J Engmann, C Dale, S Shah, J White… - PloS one, 2013 - journals.plos.org
… variants influencing cardiometabolic traits and disease outcomes through genome wide …
new questions have arisen regarding the population relevance, mechanisms, and applications …

Importance of genetic studies of cardiometabolic disease in diverse populations

L Fernández-Rhodes, KL Young, AG Lilly… - Circulation …, 2020 - Am Heart Assoc
… of the genetic underpinnings of cardiometabolic disease. Yet, … the populations who are most
affected by cardiometabolic … in a genomic region associated with a particular trait. Diverse …

[PDF][PDF] Association of structural variation with cardiometabolic traits in Finns

L Chen, HJ Abel, I Das, DE Larson, L Ganel… - The American Journal of …, 2021 - cell.com
… bolic traits, we identified 15 genome-wide … population bottlenecks and expansions—which
mirrors the findings from our recent study of coding variation, where many cardiometabolic trait

Pedigree-and SNP-associated genetics and recent environment are the major contributors to anthropometric and cardiometabolic trait variation

C Xia, C Amador, J Huffman, H Trochet… - PLoS …, 2016 - journals.plos.org
… Here we take advantage of genome-wide data and a large … on 16 anthropometric and
cardiometabolic traits. By analysing … phenotypic variation for these traits in our population. We find …

Genetic risk scores for cardiometabolic traits in sub-Saharan African populations

K Ekoru, AA Adeyemo, G Chen… - International Journal …, 2021 - academic.oup.com
… studies in which genome-wide risk scores with correction for LD structure did not yield a
uniform improvement in predictive power across all traits and all populations evaluated in the …

CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits

LD Parnell, BA Blokker, HS Dashti, PD Nesbeth… - BioData mining, 2014 - Springer
cardiometabolic traits over the past three years, there also have been a few large-scale or
genome… interactions with obesity traits and smoking in an Argentinean population of European …

Obesity genomics and metabolomics: a nexus of cardiometabolic risk

JA Regan, SH Shah - Current cardiology reports, 2020 - Springer
… Overweight and obesity in the majority of the population operates as a prototypical common
complex disease. Early genome-wide studies that attempted discovery beyond candidate …

Health Disparities in Cardiometabolic Traits: Genomics, Gaps, and Paradoxes

AR Bentley - The FASEB Journal, 2022 - Wiley Online Library
… of genomics is less clear. This presentation will consider health disparities in cardiometabolic
traits and the role of genomics … serum lipids and African ancestry populations. Serum lipids (…

Obesity genetics and cardiometabolic health: Potential for risk prediction

DK Sanghera, C Bejar, S Sharma… - Diabetes, Obesity …, 2019 - Wiley Online Library
genome sequencing in high-risk or susceptible populations.151 Furthermore, a potentially
productive and accurate prediction strategy for complex traits … poor cardiometabolic outcomes, …

Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank

SJ Jurgens, SH Choi, VN Morrill, M Chaffin… - Nature …, 2022 - nature.com
genome-wide association studies (GWAS) have provided critical insights into the genetic
architecture of cardiometabolic traits … of cardiometabolic disease in the general population, we …