Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits

KAC Meeks, AR Bentley, MH Gouveia, G Chen… - Genome Medicine, 2021 - Springer
… in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2 …
populations. In order to improve our understanding of the biology of cardiometabolic traits, we …

Cardio-metabolic parameters are associated with genetic admixture estimates in a pediatric population from Colombia

AM Muñoz, CM Velásquez, G Bedoya - BMC genetics, 2016 - Springer
… American populations influence an individual’s susceptibility to cardio-metabolic disorders.
… on a series of cardio-metabolic risk factors in a young admixed population from Colombia. …

Prevalence of adiposity and associated cardiometabolic risk factors in the samoan genome‐wide association study

NL Hawley, RL Minster, DE Weeks… - American Journal of …, 2014 - Wiley Online Library
… rising level of cardiometabolic conditions among Samoans. … in adiposity and abnormalities
in cardiometabolic traits, there is … Our study population is derived from the independent nation …

Shared genetic underpinnings of childhood obesity and adult cardiometabolic diseases

F Tekola-Ayele, A Lee, T Workalemahu… - Human genomics, 2019 - Springer
… Obesity during childhood can lead to increased risk of adverse cardiometabolic diseases …
with childhood BMI and 15 adult cardiometabolic traits using a unified statistical approach that …

Common and rare variants associated with cardiometabolic traits across 98,622 whole-genome sequences in the All of Us research program

X Wang, J Ryu, J Kim, A Ramirez, KR Mayo… - Journal of human …, 2023 - nature.com
… by providing various types of data in diverse human populations. Here we present a
demonstration project validating the program’s genomic data in 98,622 participants. We sought to …

[HTML][HTML] Genetic insights into cardiometabolic risk factors

JB Whitfield - The Clinical Biochemist Reviews, 2014 - ncbi.nlm.nih.gov
… overlap as ‘cardiometabolic’ risk. Over the past few years many genome-wide association
… , but they are correlated in the general population. To some extent the correlations will be …

Genetic variation in cardiometabolic traits and medication targets and the risk of hypertensive disorders of pregnancy

MC Honigberg, M Chaffin, K Aragam, DL Bhatt… - Circulation, 2020 - Am Heart Assoc
… In addition, HDPs are associated with heightened future risk of cardiometabolic
cardiometabolic risk is unclear. Here, we tested whether genetic predisposition to cardiometabolic

Nonconserved long intergenic noncoding RNAs associate with complex cardiometabolic disease traits

AS Foulkes, C Selvaggi, T Cao… - … , and vascular biology, 2021 - Am Heart Assoc
genome-wide studies for complex cardiometabolic traits fall in intergenic regions, and many
of these overlap genomic … be causal elements for cardiometabolic trait associations at these …

Genetic overlap between birthweight and adult cardiometabolic diseases has implications for genomic medicine

F Tekola-Ayele, A Lee, T Workalemahu, W Zhang… - Scientific reports, 2019 - nature.com
… The study facilitates our understanding of the genetic mechanisms that underlie associations
of early life growth with later life cardiometabolic traits, reproducibly shown in several …

Population scale whole genome sequencing provides novel insights into cardiometabolic health

Y Zhao, S Lockhart, J Liu, X Li, A Cortes, X Hua… - medRxiv, 2024 - medrxiv.org
In addition to its coverage of the non-coding genome, whole genome sequencing (WGS) may
better capture the coding genome than exome sequencing. We sought to exploit this and …