Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study
… genomic data, and taking into consideration the high genetic diversity of African populations…
non-communicable diseases, especially cardiometabolic diseases, on the African continent. …
non-communicable diseases, especially cardiometabolic diseases, on the African continent. …
Genes, environment, and African ancestry in cardiometabolic disorders
AP Doumatey, AR Bentley, R Akinyemi… - Trends in Endocrinology …, 2023 - cell.com
… , we discuss cardiometabolic diseases and traits in the context of African descent populations,
… in African ancestry individuals is the increasing contribution of genomic studies of African …
… in African ancestry individuals is the increasing contribution of genomic studies of African …
Association of genome-wide polygenic risk score for body mass index with cardiometabolic health from childhood through midlife
… its derivation in a European ancestry population, limited our ability to evaluate the
relevance of genetic information for informing cardiometabolic health through midlife in these …
relevance of genetic information for informing cardiometabolic health through midlife in these …
[HTML][HTML] Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci
… understudied South Asian population, strengthen and expand the knowledge base of the
genetic determinants of lipids and their association with cardiometabolic disease-related loci. …
genetic determinants of lipids and their association with cardiometabolic disease-related loci. …
A Genome-Wide Association Study Reveals a Quantitative Trait Locus of Adiponectin on CDH13 That Predicts Cardiometabolic Outcomes
… Although the ADIPOQ and ARL15 genes identified by genome-wide association studies (GWAS)
have been associated with adiponectin levels in white populations (14–16), whether …
have been associated with adiponectin levels in white populations (14–16), whether …
[HTML][HTML] Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases
T Kiiskinen, P Helkkula, K Krebs, J Karjalainen… - Nature medicine, 2023 - nature.com
… -based strategies for identifying cardiometabolic risk loci and provide genome-wide tools for
… risk factors for cardiometabolic diseases. We conduct a genetic population-based biobank …
… risk factors for cardiometabolic diseases. We conduct a genetic population-based biobank …
Gene-environment interactions of circadian-related genes for cardiometabolic traits
… In cross-sectional meta-analyses of large population-based cohorts from the Cohorts for
Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, we tested …
Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, we tested …
[HTML][HTML] Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals
… We apply new approaches to the transferability of genomic risk loci across populations,
perform ancestry-specific and trans-ancestry Mendelian randomisation analysis, investigate the …
perform ancestry-specific and trans-ancestry Mendelian randomisation analysis, investigate the …
[HTML][HTML] The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition
D van der Meer, TP Gurholt, IE Sønderby… - Communications …, 2022 - nature.com
… Finally, adjacent genomic loci were merged if separated by less than 250 KB. Allele LD
correlations were computed from EUR population of the 1000 genomes Phase 3 data. We made …
correlations were computed from EUR population of the 1000 genomes Phase 3 data. We made …
[HTML][HTML] Whole genome association study of the plasma metabolome identifies metabolites linked to cardiometabolic disease in black individuals
UA Tahir, DH Katz, J Avila-Pachecho, AG Bick… - Nature …, 2022 - nature.com
… SCARB1 plays a key role in lipoprotein metabolism through its action on reverse cholesterol
transport and is associated with cholesterol levels in large population genomic studies 42 . …
transport and is associated with cholesterol levels in large population genomic studies 42 . …