First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis

JA Roberts, CMJ Kirkpatrick, MS Roberts… - International journal of …, 2010 - Elsevier
… the population pharmacokinetics of piperacillin in critically ill patients with sepsis during
first dose and at steady state. The data describe significantly different pharmacokinetic

Systematic comparison of the population pharmacokinetics and pharmacodynamics of piperacillin in cystic fibrosis patients and healthy volunteers

JB Bulitta, SB Duffull, M Kinzig-Schippers… - Antimicrobial agents …, 2007 - Am Soc Microbiol
… Therefore, we compared the population PK and pharmacodynamics (PD) of piperacillin
received 4 g piperacillin as a 5-min intravenous infusion. We determined piperacillin levels by …

Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with complicated intra-abdominal infection

C Li, JL Kuti, CH Nightingale… - Journal of …, 2005 - academic.oup.com
… The primary objective of this study was to explore the population pharmacokinetics of
piperacillin and tazobactam in hospitalized patients with complicated intra-abdominal infections, …

Population pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese and nonobese patients

EK Chung, SC Cheatham, MR Fleming… - … Pharmacology, 2015 - Wiley Online Library
… of piperacillin/tazobactam in hospitalized obese and … -state population pharmacokinetics of
piperacillin and tazobactam, … evaluate the pharmacodynamics of piperacillin and tazobactam …

Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic …

E Asín-Prieto, A Rodríguez-Gascón… - Journal of …, 2014 - academic.oup.com
piperacillin and tazobactam pharmacokinetic parameters during critical illness and the lack
of population pharmacokinetic … a better understanding of piperacillin/tazobactam disposition …

Population pharmacokinetics and pharmacodynamics of piperacillin in critically ill patients during the early phase of sepsis

W Sukarnjanaset, S Jaruratanasirikul… - … and Pharmacodynamics, 2019 - Springer
… This study aimed to characterize the population pharmacokinetics (PKs) of piperacillin and
investigate probability of target attainment (PTA) and cumulative fraction of response (CFR) of …

Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients

SAM Dhaese, JA Roberts, M Carlier… - International journal of …, 2018 - Elsevier
… estimates from population pharmacokinetic models based on … the population pharmacokinetics
of piperacillin when infused … piperacillin were available for population pharmacokinetic

Piperacillin-tazobactam in intensive care units: a review of population pharmacokinetic analyses

I El-Haffaf, JA Caissy, A Marsot - Clinical pharmacokinetics, 2021 - Springer
… changes present in this population that alter the drug’s pharmacokinetics. This review
summarizes the population pharmacokinetic models developed for piperacillin-tazobactam and …

Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with nosocomial infections

R Chen, Q Qian, M Sun, C Qian, S Zou, M Wang… - … and pharmacokinetics, 2016 - Springer
… The study was to establish a population pharmacokinetic (PPK) model of piperacillin (PIP)
and tazobactam (TAZ) that explain pharmacokinetic variability and to propose optimized …

Population pharmacokinetics of piperacillin at two dose levels: influence of nonlinear pharmacokinetics on the pharmacodynamic profile

CB Landersdorfer, JB Bulitta… - Antimicrobial agents …, 2012 - Am Soc Microbiol
… There is evidence for a possible saturable elimination of piperacillin. Therefore, the … and
3,000 mg of piperacillin as 5-min intravenous infusion. Population pharmacokinetics based on …