… A recombinant B-domain-deleted FVIII, porcine sequence (OBI-1) … Phase 1 and Phase 2
studies with OBI-1 demonstrated … Recently, management of bleeding with OBI-1 in one patient …

… , porcine sequence FVIII (OBI-1) that is not generally susceptible to the inhibitory activity of
anti-human FVIII antibodies. Treatment with OBI-1 … OBI-1 enables measurement of FVIII levels, …

… sequence coding for OBI-1 was 9-fold increased compared with cells transfected with the
sequence … -M cells stably transfected with the sequence coding for OBI-1 or human B domain-…

… FVIII (recombinant), porcine sequence (OBI-1) that is less susceptible to the … -porcine FVIII
(pFVIII) antibodies was reported not to correlate with the efficacy of a plasma-derived pFVIII 1 . …

… Hyate:C, a low-purity preparation from porcine plasma, was the … porcine FVIII product, has
been approved in the USA for treatment of AHA. There is a high level of amino acid sequence …

… As a result of sequence variation between human and porcine FVIII, there is reduced cross-…
of recombinant porcine FVIII, OBI-1, in humans. Results from this study suggest that OBI-1 is …

… standard is required for measurement of OBI-1 levels in the patient’s plasma. However, for
detection and measurement of porcine antibodies it is necessary for laboratories to use OBI-…

… OBI-1 is a recombinant porcine sequence FVIII developed to … OBI-1 is a recombinant porcine
sequence FVIII developed to … OBI-1’s utilization during the treatment phase in the OBI-…

… The phylogenetic analysis of the sequences and other references formed two distinct clades
in which all the PPV1 sequences from this study grouped together in clade 1 with virulent …

… animal viruses and include porcine circovirus type 1 (PCV1) and porcine circovirus type 2
(… 1). Both the nucleotide and amino acid sequence alignments of the PCV2 sequences from …