… of selective EGFR-TKIs suitable for use as anticancer agents has … c-erbB-2 receptor with a
similar potency. Both compounds cause a … A class of potent EGFR-TKIs is represented by the …

… Taking compound 1 as lead compound, Chen and his colleagues discovered a novel
series of diaminopyrimidine derivates as potent EGFR L858R/T790M inhibitors with improved …

… EGFR has yet been reported. In a systematic effort to design potent inhibitors of EGFR as
anticancer agents … the structure of the EGFR kinase domain and this model was used to design …

… research on anticancer compounds with EGFR TK inhibitory … -pyrazoline derivatives as
anticancer agents. Biological … would be a potent anticancer agent with significant EGFR TK …

… factor receptor (EGFR) inhibition capability … potent EGFR inhibition with IC 50 in nanomolar
range of 110 ± 0.14 to 30 ± 0.25 nM. The compounds (4b) and (9b) displayed the most potent …

… is the EGFR family. The synonyms and discovery of four members of the EGFR family: EGFR,
… in a biochemical experiment, indicating around 43-fold more potency than EGFR WT (IC 50 …

… reported as potent anticancer agents targeting EGFR and HER… their anticancer activities
were evaluated as potential EGFR … the most potent inhibitory activity EGFR and HER-2 (IC 50 …

… (EGFR). The synthesized compounds were further tested for their inhibitory activity on EGFR
… 5d and 5e displayed the most potent inhibitory activity on EGFR with IC 50 equal to 2.09 …

… their inhibitory activity against EGFR-TK. The … potency of these derivatives as EGFR inhibitors,
but we need further exploration to get more details about their mode of binding with EGFR …

… forms, and compound 11 b emerged as the most potent EGFR inhibitor with IC 50 values
of 0.09 and 4.03 μM against EGFR WT and EGFR T790M , respectively. In order to get an …