Biological activities and potential molecular targets of cucurbitacins: a focus on cancer

X Chen, J Bao, J Guo, Q Ding, J Lu, M Huang… - Anti-cancer …, 2012 - journals.lww.com
Potential molecular targets for cucurbitacins. F-actin and STAT3 are the two main identified
molecular targets for cucurbitacins to date. Cucurbitacins markedly affect the disruption, …

NF‐κB as a potential molecular target for cancer therapy

CH Lee, YT Jeon, SH Kim, YS Song - Biofactors, 2007 - Wiley Online Library
Nuclear factor κB (NF‐κB), a transcription factor, plays an important role in carcinogenesis
as well as in the regulation of immune and inflammatory responses. NF‐κB induces the …

PRL phosphatases as potential molecular targets in cancer

BJ Stephens, H Han, V Gokhale, DD Von Hoff - Molecular cancer …, 2005 - AACR
The phosphatase of regenerating liver (PRL) family of phosphatases, consisting of PRL-1,
PRL-2, and PRL-3, represents an intriguing group of proteins being validated as biomarkers …

[HTML][HTML] Tea polyphenols, their biological effects and potential molecular targets

D Chen, V Milacic, MS Chen, SB Wan… - Histology and …, 2008 - ncbi.nlm.nih.gov
… A major challenge of cancer prevention is to integrate new molecular findings into clinical
practice. Therefore, identification of more molecular targets and biomarkers for tea …

NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy

HM Shen, V Tergaonkar - Apoptosis, 2009 - Springer
… support the notion that NFκB acts as the molecular link bridging inflammation and cancer.
As a result, NFκB becomes an ideal molecular target in controlling cancer development. In fact, …

Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention

KS Chun, YJ Surh - Biochemical pharmacology, 2004 - Elsevier
… The present review covers the signal transduction pathways responsible for regulating
COX-2 expression as novel molecular targets of chemopreventive agents with celecoxib as a …

Strategies and potential molecular targets for obesity treatment

LA Campfield, FJ Smith, P Burn - Science, 1998 - science.org
… revealed new biochemical pathways and molecular targets for pharmacological intervention
that … Here, we discuss some of the potential drug targets that have emerged from this “new …

Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models1

KH Kwon, A Barve, S Yu, MT HUANG… - Acta Pharmacologica …, 2007 - Wiley Online Library
… as potential molecular targets for chemoprevention by dietary phytochemicals[4]. The
scope of the present review will focus on the molecular basis of chemopreventive potential of …

Drugs and their molecular targets: an updated overview

Y Landry, JP Gies - Fundamental & clinical pharmacology, 2008 - Wiley Online Library
… selectivity in the main superfamilies of drug targets, enzymes, membrane transporters and
… with their molecular target and therapeutic interest. The druggability of emerging targets is …

Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection

H Chen, H Yoshioka, GS Kim, JE Jung… - Antioxidants & redox …, 2011 - liebertpub.com
… determinant for ischemic damage/repair and that these major anti- and pro-oxidant enzymes
are potential endogenous molecular targets for stroke therapy. Antioxid. Redox Signal. …