Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets
A Ayala, M Perl, F Venet, J Lomas-Neira… - Current …, 2008 - ingentaconnect.com
… the target cell in a given tissue/ organ to perceive these death receptor stimuli as either an
apoptotic… into the pathobiology of sepsis, but also suggests possible therapeutic targets for the …
apoptotic… into the pathobiology of sepsis, but also suggests possible therapeutic targets for the …
The pathogenesis of sepsis and potential therapeutic targets
M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
… brings about abnormal apoptosis in sepsis animals, suggesting that ER stress-mediated
apoptosis represents a potential new target for clinical prevention and treatment for sepsis. …
apoptosis represents a potential new target for clinical prevention and treatment for sepsis. …
The apoptotic pathway as a therapeutic target in sepsis
DE Wesche-Soldato, RZ Swan, CS Chung… - … drug targets, 2007 - ingentaconnect.com
… cally successful therapies … apoptotic pathway within the immune system is the topic of current
investigation. Prior to discussing the apoptotic pathway as a potential target for drug therapy…
investigation. Prior to discussing the apoptotic pathway as a potential target for drug therapy…
Apoptosis in sepsis: a new target for therapeutic exploration
C Oberholzer, A Oberholzer, M Clare-Salzler… - The FASEB …, 2001 - Wiley Online Library
… for the septic patient. In the current review, we address the scientific rationale for modifying
apoptotic pathways in sepsis syndrome and propose several potential therapeutic targets. …
apoptotic pathways in sepsis syndrome and propose several potential therapeutic targets. …
Novel therapeutic targets for sepsis: regulation of exaggerated inflammatory responses
… of apoptotic cells is one of the major hallmarks of sepsis. Sepsis decreases apoptotic …
understanding, and may shed light on novel therapeutic targets for the treatment of sepsis. …
understanding, and may shed light on novel therapeutic targets for the treatment of sepsis. …
The role and mechanism of pyroptosis and potential therapeutic targets in sepsis: a review
X Zheng, W Chen, F Gong, Y Chen, E Chen - Frontiers in immunology, 2021 - frontiersin.org
… Recently was been found that pyroptosis is a unique form of proinflammatory programmed
death, that is different from apoptosis. A growing number of studies have investigated …
death, that is different from apoptosis. A growing number of studies have investigated …
Signaling pathways and intervention therapies in sepsis
Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
… , potential molecular mechanism, and pathway-associated therapy in sepsis. Host-derived
molecules interacting with activated cells possess pivotal role for sepsis pathogenesis by …
molecules interacting with activated cells possess pivotal role for sepsis pathogenesis by …
Considering immunomodulatory therapies in the septic patient: should apoptosis be a potential therapeutic target?
A Oberholzer, C Oberholzer, RM Minter, LL Moldawer - Immunology Letters, 2001 - Elsevier
… Although clinical trials with anti-apoptotic agents remain distant due in large part to … ,
inhibition of lymphocyte apoptosis may be an appropriate therapeutic target for the septic patient. …
inhibition of lymphocyte apoptosis may be an appropriate therapeutic target for the septic patient. …
The immunopathology of sepsis and potential therapeutic targets
T van der Poll, FL van de Veerdonk… - Nature Reviews …, 2017 - nature.com
… -induced inflammation, they also have dysfunctional features that impair their antimicrobial
capacities; key findings in sepsis are the delayed apoptosis of neutrophils and the …
capacities; key findings in sepsis are the delayed apoptosis of neutrophils and the …
Intracellular lipopolysaccharide sensing as a potential therapeutic target for sepsis
A Pfalzgraff, G Weindl - Trends in Pharmacological Sciences, 2019 - cell.com
… During the late stage of sepsis, patients can suffer from severe immunosuppression due
to a higher rate of lymphocyte apoptosis and tolerance. Thus, LPS-induced pyroptosis via …
to a higher rate of lymphocyte apoptosis and tolerance. Thus, LPS-induced pyroptosis via …
相关搜索
- potential therapeutic targets immunopathology of sepsis
- potential therapeutic targets cytokines in sepsis
- potential therapeutic targets pathogenesis of sepsis
- potential therapeutic target septic patient
- potential therapeutic targets mechanism of pyroptosis
- potential therapeutic targets clinical impact
- apoptotic pathway therapeutic target in sepsis
- apoptosis in sepsis therapeutic exploration
- potential therapeutic target lipopolysaccharide sensing
- apoptosis in sepsis role and regulation
- apoptotic cell death in sepsis
- rational therapeutic strategy blockade of apoptosis
- apoptosis and caspases inflammation in sepsis
- sepsis and shock leukocyte apoptosis
- septic shock apoptosis and inflammation
- therapeutic implications immune cell apoptosis