… the target cell in a given tissue/ organ to perceive these death receptor stimuli as either an
apoptotic… into the pathobiology of sepsis, but also suggests possible therapeutic targets for the …

… lead to caspasemediated apoptosis, represent an attractive therapeutic target for the septic
… apoptotic pathways in sepsis syndrome and propose several potential therapeutic targets. …

… apoptotic pathway within the immune system is the topic of current investigation. Prior to
discussing the apoptotic pathway as a potential target for drug therapy, … Intensive insulin therapy …

… brings about abnormal apoptosis in sepsis animals, suggesting that ER stress-mediated
apoptosis represents a potential new target for clinical prevention and treatment for sepsis. …

… Recently was been found that pyroptosis is a unique form of proinflammatory programmed
death, that is different from apoptosis. A growing number of studies have investigated …

… -induced inflammation, they also have dysfunctional features that impair their antimicrobial
capacities; key findings in sepsis are the delayed apoptosis of neutrophils and the …

… apoptosis may be an appropriate therapeutic target for the septic patient. … target only
the apoptotic lymphocyte, and to transiently block the increased apoptosis only during sepsis …

… During the late stage of sepsis, patients can suffer from severe immunosuppression due
to a higher rate of lymphocyte apoptosis and tolerance. Thus, LPS-induced pyroptosis via …

… Low Bax/Bcl-2 protein ratios are found in antiapoptotic states, which might be beneficial in
the recovery from sepsis as high apoptotic rates of immune cells were shown to contribute to …

… of apoptotic cells is one of the major hallmarks of sepsis. Sepsis decreases apoptotic …
understanding, and may shed light on novel therapeutic targets for the treatment of sepsis. …