… Low Bax/Bcl-2 protein ratios are found in antiapoptotic states, which might be beneficial in
the recovery from sepsis as high apoptotic rates of immune cells were shown to contribute to …

… critical role of cell apoptosis in the pathophysiology of sepsis … apoptotic cell death in sepsis,
and emphasizes the potential value … that siRNA therapy may offer a unique alternative sepsis …

… a potential therapeutic strategy. Problems facing the development of effective and safe caspase
therapeutics will … Increased lymphocyte apoptosis may occur in sepsis contributing to the …

… manipulating apoptosis could be a new therapeutic approach in sepsis. Further, exploring
potential therapeutic targets related to apoptosis will be valuable in reversing sepsis-induced …

… the lymphocyte in sepsis in controlling infection, it also illustrates a clear therapeutic target,
which might … Yet another target that decreases lymphocyte apoptosis is Akt, a regulator of cell …

… mice and attenuates liver injury, inflammation, and apoptosis in the CLP septic model [105].
In the LPS-treated model, complete autophagic response is induced in hepatocytes [107, 108…

… enzymes and subsequently undergo apoptotic cell death. Upon … remove the cell debris of
apoptotic neutrophils in order to … extracellular HMGB1 as a potential novel therapeutic target. …

… a number of potential therapeutic targets that may be exploited in the future treatment of
severe sepsis. … Lymphocyte apoptosis is accelerated during sepsis and can be exacerbated by …

… The ER-β is an important therapeutic target because it is not involved in the proliferative …
and LPS-induced activation of pro-apoptotic pathways. It reduced the mortality by greater than 50…

… The prevalent hypothesis regarding the mechanisms of sepsis and septic shock indicates …
conditions, including sepsis. This review considers the process of sepsis from a mitochondrial …