[HTML][HTML] Role of vimentin in modulating immune cell apoptosis and inflammatory responses in sepsis

L Su, P Pan, P Yan, Y Long, X Zhou, X Wang, R Zhou… - Scientific reports, 2019 - nature.com
… or therapeutic targets for sepsissepsis and septic shock compared to controls and that VIM
expression was significantly increased in lymphocytes isolated from septic shock and sepsis

Molecular biology of inflammation and sepsis: a primer

I Cinel, SM Opal - Critical care medicine, 2009 - journals.lww.com
… survival in a model of severe peritonitis, despite the marked decrease in sepsis-induced
T and B lymphocyte apoptosis suggesting MyD88, like NF-κB, is also critical host survival in …

Mechanisms and treatment of organ failure in sepsis

C Lelubre, JL Vincent - Nature Reviews Nephrology, 2018 - nature.com
apoptosis during sepsis 66 by a process that is largely dependent on the anti-apoptotic
represent clear targets for potential therapies to limit sepsis-induced organ dysfunction. …

Anti-inflammatory mechanisms of sepsis

NJ Shubin, SF Monaghan, A Ayala - Sepsis-Pro-Inflammatory and Anti …, 2011 - karger.com
apoptotic cells and debris. In this regard, preventing apoptosis during sepsis may be a potential
therapeutic target… current molecular biological therapeutic for sepsis is activated protein C…

Autophagy regulation on pyroptosis: mechanism and medical implication in sepsis

R Guo, H Wang, N Cui - Mediators of inflammation, 2021 - Wiley Online Library
… In HIV infection, caspase-3-mediated apoptosis has been proposed as the key mechanism
… axis and potential therapeutic targets. New drugs have been developed to target every …

Immune dysfunction in murine polymicrobial sepsis: mediators, macrophages, lymphocytes and apoptosis

A Ayala, IH Chaudry - Shock, 1996 - journals.lww.com
… antibiotic therapy, aggressive operative intervention and intravenous hyperalimentation,
sepsis, … underlying the pathophysiology of sepsis so that better therapeutic interventions can be …

Assessment of apoptosis inhibitor of macrophage/CD5L as a biomarker to predict mortality in the critically ill with sepsis

X Gao, Y Liu, F Xu, S Lin, Z Song, J Duan, Y Yin, J Cao - Chest, 2019 - Elsevier
therapeutic target for treating experimental sepsis. However, to our knowledge, the role of
AIM in human sepsis … ICU admission in patients with sepsis is a potential biomarker for patient …

[HTML][HTML] The role of autophagy in sepsis: protection and injury to organs

X Yin, H Xin, S Mao, G Wu, L Guo - Frontiers in physiology, 2019 - frontiersin.org
… failures in sepsis. In addition, it is necessary to further identify potential therapeutic targets in
… an increase in apoptosis and pulmonary edema. Current research indicates that excessive …

[HTML][HTML] Extracellular histones activate autophagy and apoptosis via mTOR signaling in human endothelial cells

JS Ibañez-Cabellos, C Aguado… - … et Biophysica Acta (BBA …, 2018 - Elsevier
… of sepsis, and consequently as novel therapeutic targets in human diseases [10]. Importantly,
interactions between histones and TLRs have been related to cell death in some cell types […

Apoptotic cell clearance in the tumor microenvironment: a potential cancer therapeutic target

SA Shin, SY Moon, D Park, JB Park, CS Lee - Archives of pharmacal …, 2019 - Springer
… conditions such as infection or other diseases related to acute tissue injury. Swift … in apoptotic
cell clearance as potential therapeutic target for clinical cancer therapy in the near future. …